Post-mortem Studies of Dopaminergic Function in Schizophrenia
Since its inception in 1965 (Randrup & Munkvad 1965), the dopamine hypothesis of schizophrenia has been extremely rewarding in terms of generating investigation. In its simplest form the hypothesis proposes that an increase in brain dopaminergic function may be responsible for the production of some of the symptoms of schizophrenia. Two major lines of evidence support the hypothesis. Firstly the dopamine receptor antagonism displayed by neuroleptics correlates with, and may be the only pre-requisite for their anti-psychotic action (Creese et al 1976, Seeman et al 1976, Johnstone et al 1978). Secondly, dopamine-potentiating drugs such as amphetamine can induce a schizophrenia-like paranoid state in non-psyohotic individuals, and worsen the pre-existing psychosis of schizophrenia (Connell 1958, Angrist et al 1974).
KeywordsHPLC Dopamine Dementia Schizophrenia Choline
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