The Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia

  • Robert H. Lamotte
Part of the Wenner-Gren Center International Symposium Series book series (WGS)

Abstract

Neurophysiological studies have demonstrated the existence of cutaneous nociceptors that respond with graded discharge to noxious heat stimuli of different temperatures. The studies have also shown that certain nociceptors can be sensitized to heat after cutaneous heat injury (Beitel and Dubner, 1976a,b, Bessou and Perl, 1969, Campbell et al., 1979, Fitzgerald and Lynn, 1977, Iggo, 1959, Kumazawa and Perl, 1977, Lynn, 1979, 1980, Meyer and Campbell, 1981, Perl et al., 1976, Torebjörk and Hallin, 1974). These results indicate a role of cutaneous nociceptors in heat pain and the hyperalgesia that develops after cutaneous injury. However, no clear relationship between nociceptor responses and the sensation of pain can be established until combined neurophysiological and psychophysical studies are carried out in the same or related species using the same set of experimental stimuli. With this idea in mind, my colleagues and I have investigated some peripheral neural mechanisms of cutaneous heat pain and hyperalgesia (LaMotte et al., 1982, 1983, Torebjörk et al., 1984).

Keywords

Fatigue Depression Stimul 

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Copyright information

© The Wenner-Gren Center 1984

Authors and Affiliations

  • Robert H. Lamotte
    • 1
  1. 1.Department of AnesthesiologyYale University School of MedicineNew HavenUSA

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