Problems Involved in Interpreting Lithium-induced Behaviour Change
In chapter 4 a number of factors were outlined which led to difficulties in interpreting the effects of lithium on motor activity. Such issues are not, of course, specific to that particular facet of behaviour, and it is always necessary for the investigator to bear in mind that his findings may depend upon such things as the species, strain, sex and age of the experimental subjects, the dose, physical form and route administration of the drug being administered, the time of behavioural testing relative to drug administration and the time of administration relative to the animal’s circadian cycle, the physical conditions under which the experiment is performed, and so on—not to mention the difficulty of unequivocally interpreting the results of the given behavioural test being used.
KeywordsToxicity Lithium Attenuation Cage Sodium Chloride
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