Abstract
The use of haemoperfusion with charcoal and resin adsorbents has proved to be effective in severe, life-threatening intoxications for those drugs which have a relatively small distribution volume. However, uncertainty remains about the precise role of haemoperfusion in the treatment of severe overdose. While many different haemoperfusion devices have become commercially available since the first one appeared in 1975, none of these is based on powder adsorbents. The influence of particle size has been recognised by several groups who have either encapsulated powder in beads (Holloway et al., 1979), fibres (Davis et al., 1974; Gundermann et al., 1981), membranes (Malchesky et al., 1977) or upon beads (Lauterburg et al., 1979). The advantages of small particles disappeared in most of the experimental devices, due to the limited permeability of the ‘coatings’. At the Eindhoven University of Technology, the socalled ‘filmadsorber’, containing powder charcoal embedded in a collodion film has been developed (Rietema and van Zutphen, 1975; van Berlo et al., 1982) . In order to compare this kind of powder adsorbent column with the existing devices, the adsorption isotherms and intraparticle diffusivities of five adsorbents with five toxins were determined in vitro. In this study, a special apparatus was
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© 1984 Bioengineering Unit, University of Strathclyde
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van Berlo, A.M.W., Poelmans, A.P., van der Pols, E.P., Aarts, P.J.M., Verkooyen, A.H.M. (1984). Comparing In Vitro Adsorption Studies With The Filmadsorber And Other Haemoperfusion Devices. In: Paul, J.P., Gaylor, J.D.S., Courtney, J.M., Gilchrist, T. (eds) Biomaterials in Artificial Organs. Strathclyde Bioengineering Seminars. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07283-5_21
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