Pharmacokinetics and Patient Care

  • G. P. Mould


In the past few years, pharmacokinetics has been establishing itself as an essential part of patient care. Its use by different members of the health care team has been variable, which in part may be due to the number of apparently complicated formulae and different symbols that are used. Nevertheless, when relating pharmacokinetics to the clinical situation, in which case it is more appropriately called clinical pharmacokinetics, a few simple guidelines enable pharmacokinetic data to be used in an uncomplicated fashion during patient care. This should lead to a more rational use of drug therapy and thus result in an improvement in patient care.


Therapeutic Drug Monitoring Clinical Pharmacokinetic Target Range Elimination Rate Constant Sodium Valproate 
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  1. Aaronson, J. K. (1980). Clin. Pharmacokin. 5, 137–49.CrossRefGoogle Scholar
  2. Aaronson, J. K., and Grahame-Smith, D. G. (1976). Brit. J. Clin. Pharmacol. 3, 1045–51.CrossRefGoogle Scholar
  3. Aaronson, J. K., Grahame-Smith, D. G., and Wigley, F. M. (1978). Quart. J. Med. 47, 111–22.Google Scholar
  4. Bateman, D. N., Kahn, C., and Davies, D. S. (1980). Brit. J. Clin. Pharmacol. 9, 371–7.CrossRefGoogle Scholar
  5. Borga, O., Piafsky, K. M., and Nilsen, G. (1977). Clim. Pharmacol. Ther. 22, 539–44.CrossRefGoogle Scholar
  6. Boyd, J., Covington, T. R., and Stanaszek, W. F. (1974). Am. J. Hosp. Pharm. 31, 362–7.PubMedGoogle Scholar
  7. Braithwaite, R., Montgomery, S., and Dawling, S. (1978). Clin. Pharmacol. Ther. 23, 303–8.CrossRefPubMedGoogle Scholar
  8. Brooker, G., and Jelliffe, R. W. (1972). Circulation 45, 20–36.CrossRefPubMedGoogle Scholar
  9. Burnett, G. H., and Conklin, R. L. (1968). J. Lab. Clin. Med. 71, 1040–50.PubMedGoogle Scholar
  10. Chang, J. J., Crowl, C. P., and Schneider, R. S. (1975). Clin. Chem. 21, 967.Google Scholar
  11. Cooper, T. B., Bergner, P.-E. E., and Simpson, G. M. (1973). Am. J. Psychiatr. 130, 601–3.CrossRefPubMedGoogle Scholar
  12. Cooper, T. B., and Simpson, G. M. (1978). Am. J. Psychiatr. 135, 333–5.CrossRefPubMedGoogle Scholar
  13. Curry, S. H. (1968). Analyt. Chem. 40, 1251–6.CrossRefGoogle Scholar
  14. Curry, S. H. (1980). Drug Disposition and Pharmacokinetics (3rd ed.), Blackwell Scientific Publications, Oxford, 131–44.Google Scholar
  15. Curry, S. H., Mould, G. P., and D’Mello, A. (1971). Brit. J. Pharmacol. 42, 403–11.CrossRefGoogle Scholar
  16. Dawling, S., Crome, P., and Braithwaite, R. (1980). Clin. Pharmacokin. 5, 394–401.CrossRefGoogle Scholar
  17. Dhillon, S., Oxley, J., and Richens, A. (1982). Brit. J. Clin. Pharmacol. 13, 427–32.CrossRefGoogle Scholar
  18. Dobbs, S. M., Mawer, G. E., Rodgers, E. M., Woodcock, B. G., and Lucas, S. B. (1977). Brit. J. Clin. Pharmacol. 3, 231–7.CrossRefGoogle Scholar
  19. Dollery, C. T., Davies, D. S., and Conolly, M. E. (1971). N.Y. Ann. Acad. Sci. 179, 109–12.CrossRefGoogle Scholar
  20. Dougall, J. R., Cunningham, B., and Nimmo, W. S. (1983). Brit. J. Clin. Pharmacol. 15, 487–9.CrossRefGoogle Scholar
  21. Eadie, M. J., Lander, C. M., and Tyrer, J. H. (1977). Clin. Pharmacokin. 2, 427–36.CrossRefGoogle Scholar
  22. George, C. F. (1979). Clin. Pharmacokin. 4, 433–48.CrossRefGoogle Scholar
  23. Gibaldi, M. (1984). Biopharmaceutics and Pharmacokinetics (3rd ed.), Lea and Febiger, Philadelphia, 17–28.Google Scholar
  24. Gibson, T. P., and Nelson, H. A. (1980). Clin. Pharmacol. Ther. 27, 219–23.CrossRefPubMedGoogle Scholar
  25. Gillis, A. M., and Kates, R. E. (1984). Clin. Pharmacokin. 9, 375–403.CrossRefGoogle Scholar
  26. Gram, L. (1977). Dan. Med. Bull. 24, 81–9.PubMedGoogle Scholar
  27. Gram, L. F., and Overo, K. F. (1975). Clin. Pharmacol. Ther. 18, 305–14.CrossRefPubMedGoogle Scholar
  28. Gugler, R., Manion, C. V., and Azarnoff, D. L. (1976). Clin. Pharmacol. Ther. 19, 135–42.CrossRefPubMedGoogle Scholar
  29. Hendeles, L., Iafrate, R. P., and Weinberger, M. (1984). Clin. Pharmacokin. 9, 95–135.CrossRefGoogle Scholar
  30. Hendeles, L., Weinberger, M., and Brighley, L. (1977). Am. J. Hosp. Pharm. 34, 525–7.PubMedGoogle Scholar
  31. Holt, D. W., Tucker, G. T., Jackson, P. R., and Storey, G. C. (1983). Amer. Heart J. 106, 840–6.CrossRefPubMedGoogle Scholar
  32. Hook, G. E. R., Bend, J. H. R., Hoel, D., Foutts, J. R., and Gram, T. E. (1972). J. Pharmacol. Exp. Ther. 182, 474–90.PubMedGoogle Scholar
  33. Hunninghake, D. B., and King, S. (1978). Pharmacologist 20, 220.Google Scholar
  34. lisalo, E. (1977). Clin. Pharmacokin. 2, 1–16.CrossRefGoogle Scholar
  35. Johnston, G. D., and McDevitt, D. G. (1978). Brit. J. Clin. Pharmacol. 6, 339–43.CrossRefGoogle Scholar
  36. Kelman, A. W., Whiting, B., and Bryson, S. M. (1982). Brit. J. Clin. Pharmacol. 14, 247–56.CrossRefGoogle Scholar
  37. Kennedy, M. C., and Wade, D. M. (1979). Brit. J. Clin. Pharmacol. 7, 515–18.CrossRefGoogle Scholar
  38. Klein, H. O., Lang, R., DeSegri, E., and Kaplinsky, E. (1980). New Engl. J. Med. 303, 160.PubMedGoogle Scholar
  39. Koch-Weser, J. (1972). New Engl. J. Med. 287, 227–31.CrossRefPubMedGoogle Scholar
  40. Koup, J. R., Greenblatt, D. J., Jusko, W. J., Smith, T. W., and Koch-Weser, J. (1975). J. Pharmacokin. Biopharm. 3, 181–92.CrossRefGoogle Scholar
  41. Koup, J. R., Sack, C. M., Smith, A. L., and Gibaldi, M. (1979). Clin. Pharmacokin. 4, 460–9.CrossRefGoogle Scholar
  42. Lindenbaum, J., Mellow, M. H., Blackstone, M. O., and Butler Jr, V. P. (1970). New Engl. J. Med. 285, 1344–7.CrossRefGoogle Scholar
  43. Little, P. J., Jennings, G. L., Skews, H., and Bobik, A. (1982). Brit. J. Clin. Pharmacol. 13, 785–90.CrossRefGoogle Scholar
  44. Lott, R. S., and Hayton, W. L. (1978). Drug Intell. Clin. Pharm. 12, 140–8.Google Scholar
  45. Lowenstein, J. W., and Corrill, E. M. (1966). J. Lab. Clin. Med. 68, 1048–52.Google Scholar
  46. McNeil, J. J., and Louis, W. J. (1984). Clin. Pharmacokin. 9, 157–67.CrossRefGoogle Scholar
  47. Marks, V., Morris, B. A., and Teale, J. D. (1974). Brit. Med. Bull. 30, 80–6.PubMedGoogle Scholar
  48. Melander, A., Danielson, K., Schersten, B., and Wahn, E. (1977). Clin. Pharm. Ther. 22, 108–12.CrossRefGoogle Scholar
  49. Metzler, C. M., Elfring, G. L., and McEwan, A. J. (1974). Biometrics 30, 562–3.CrossRefGoogle Scholar
  50. Moolenaar, F., Greving, W. J., and Huizanga, T. (1982). Int. J. Pharm. 5, 127–37.CrossRefGoogle Scholar
  51. Moore, A., Sear, J., Baldwin, D., Allen, M., Hunniset, A., Bullingham, R., and McQuay, M. (1984). Clin. Pharmacol. Ther. 35, 461–5.CrossRefGoogle Scholar
  52. Mould, G. P. (1977). An Intestinal Mixed-function Oxidase System of Potential Importance in Biopharmacy. PhD Thesis, University of London.Google Scholar
  53. Mould, G. P. (1978). Brit. J. Pharmacol. Practice 3, 22–4.Google Scholar
  54. Mould, G. P., Aherne, G. W., Morris, B. A., Teale, J. D., and Marks, V. (1977). Europ. J. Drug Metab. Pharmacokin. 4, 171–84.CrossRefGoogle Scholar
  55. Mould, G. P., Clough, J., Marks, V., Levinson, N. L., Townsend, H. A., and Cummings, S. W. (1982). J. Clin. Hosp. Pharm. 7, 281–6.PubMedGoogle Scholar
  56. Mould, G. P., Clough, J., Stout, G., Morris, B. A., and Marks, V. (1981). Biopharmac. Drug Disposit. 2, 49–57.CrossRefGoogle Scholar
  57. Mould, G. P., and Marks, V. (1986). (In preparation).Google Scholar
  58. Mould, G. P., Morris, B. A., Marks, V., Malan, P. G., and Ekins, R. (1979). Abstracts of Papers and Posters — Third European Congress of Clinical Chemistry, Brighton.Google Scholar
  59. Nelson, K., and Bowers, L. D. (1983). Clin. Chem. 29, 1175.Google Scholar
  60. Neuvonen, P. J. (1979). Clin. Pharmacokin. 4, 91–103.CrossRefGoogle Scholar
  61. Nimmo, W. S., Heading, R. C., Wilson, J., Tothill, P., and Prestcott, L. F. (1975). Brit. J. Clin. Pharmacol. 2, 509–13.CrossRefGoogle Scholar
  62. Ogilvie, R. I. (1978). Clin. Pharmacokin. 3, 267–93.CrossRefGoogle Scholar
  63. Oliver Jr, G. C., Parker, B. M., Brasfield, D. L., and Parker, C. W. (1968). J. Clin. Invest. 47, 1035–42.PubMedCentralCrossRefPubMedGoogle Scholar
  64. Pederson, K. E., Dorph-Pederson, A., Hvidt, S., Klitgaard, N. A., and Neilsen-Kuds, K. F. (1981). Clin. Pharmacol. Ther. 30, 311–16.CrossRefGoogle Scholar
  65. Perucca, E., Richens, A., and Ruprah, M. (1981). Brit. J. Clin. Pharmacol. 11, 409P–10P.CrossRefGoogle Scholar
  66. Piafsky, K. M., and Borga, O. (1977). Clin. Pharmacol. Ther. 22, 545–9.CrossRefPubMedGoogle Scholar
  67. Piafsky, M., Borga, O., Odar-Cederlof, I., Johanssen, C., and Sjoqvist, F. (1979). New Engl. J. Med. 299, 1435–9.CrossRefGoogle Scholar
  68. Pudek, M. R., Seccombe, D. W., Jacobson, B. E., and Whitfield, M. F. (1983). Clin. Chem. 29, 1972–4.PubMedGoogle Scholar
  69. Ramsbottom, N., and Hunt, J. N. (1974). Digestion 10, 1–8.CrossRefPubMedGoogle Scholar
  70. Reitberg, D. P., Bernhard, H., and Schentag, J. J. (1981). Ann. Int. Med. 95, 582–5.CrossRefPubMedGoogle Scholar
  71. Richens, A. (1978). Brit. J. Clin. Pharmacol. 5, 285–8.CrossRefGoogle Scholar
  72. Richens, A., Marks, V. (eds.), (1981) Therapeutic Drug Monitoring, Churchill Livingstone, London.Google Scholar
  73. Rivera-Calimlin, L., Morgan, J. P., Dujovne, C. A., Bianchine, J. R., and Lasagna, L. (1971). Biochem. Pharmacol. 20, 3051–7.CrossRefGoogle Scholar
  74. Ross-Lee, L., Eadie, M. J., Hooper, W. D., and Bochner, F. (1981). Europ. J. Clin. Pharmacol. 20, 465–71.CrossRefGoogle Scholar
  75. Rowland, M., and Tozer, T. N. (1980). Clinical Pharmacokinetics: Concepts and Applications, Lea and Febiger, Philadelphia.Google Scholar
  76. Schapira, A. (1984). Clin. Pharmacokin. 9, 360–70.CrossRefGoogle Scholar
  77. Scheline, R. R. (1968). Pharmac. Rev. 25, 451–523.Google Scholar
  78. Shand, D. G., Hammill, S. C., Aanonsen, L., and Pritchett, E. L. C. (1981). Clin. Pharmacol. Ther. 30, 701–3.CrossRefPubMedGoogle Scholar
  79. Sheiner, L. B., and Beal, L. S. (1979). J. Pharm. Sci. 71, 1344–8.CrossRefGoogle Scholar
  80. Sheiner, L. B., Beal, S. L., Rosenberg, B., and Marathe, V. V. (1979). Clin. Pharmacol. Ther. 26, 294–305.CrossRefPubMedGoogle Scholar
  81. Shoeman, D. W., and Azarnoff, D. L. (1972). Pharmacology 7, 169–77.CrossRefPubMedGoogle Scholar
  82. Sjöqvist, F. (1984). Therapeutic drug monitoring — twenty years’ experience. In: Lemberger, L., and Reidenberg, M. M. (eds.), Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics. American Society for Pharmacology and Experimental Therapeutics, Washington, 38–63.Google Scholar
  83. Slattery, J. T., Gibaldi, M., and Koup, J. R. (1980). Clin. Pharmacokin. 5, 377–85.CrossRefGoogle Scholar
  84. Smith, T. W., Butler Jr, V. P., and Haber, E. (1969). New Engl. J. Med. 281, 1212–16.CrossRefPubMedGoogle Scholar
  85. Somogyi, A., Thielscher, S., and Gugler, R. (1981). Europ. J. Clin. Pharmacol. 19, 343–7.CrossRefGoogle Scholar
  86. Starkey, B. J., and Mould, G. P. (1984). Ther. Drug. Monit. 6, 322–7.CrossRefPubMedGoogle Scholar
  87. Steiness, E., Svendsen, O., and Rasmussen, F. (1974). Clin. Pharmacol. Ther. 16, 430–4.CrossRefPubMedGoogle Scholar
  88. Stevenson, D., Briggs, R., and Mould, G. P. (1986). J. Pharm. Biomed. Analysis (in press).Google Scholar
  89. Thomson, P. D. (1973). Ann. Int. Med. 78, 499–504.CrossRefPubMedGoogle Scholar
  90. Toothaker, R. D., and Welling, P. G. (1980). Ann. Rev. Pharmacol. Toxicol. 20, 173–99.CrossRefGoogle Scholar
  91. Tsanaclis, L. M., Allewn, J., Perucca, E., Routledge, P. A., and Richens, A. (1984). Brit. J. Clin. Pharmacol. 18, 17–20.CrossRefGoogle Scholar
  92. Tyrer, J. H., Eadie, M. J., Sutherland, J. M., and Hooper, W. D. (1971). Brit. Med. J. 4, 271–3.CrossRefGoogle Scholar
  93. Vozeh, S., Muir, K. T., Follath, F., and Sheiner, L. B. (1981). J. Pharmacokin. Biopharm. 9, 131–44.CrossRefGoogle Scholar
  94. Walker, C. A., and Kopp, B. (1978). Antimicrob. Agents Chemother. 13, 30–3.PubMedCentralCrossRefPubMedGoogle Scholar
  95. Watson, E., and Kalman, S. M. (1971). J. Chromatogr. 56, 209–18.CrossRefPubMedGoogle Scholar
  96. Welling, P. G. (1980). Pharm. Internat. 1, 14–18.Google Scholar
  97. Wilkinson, G. R., and Shand, D. G. (1975). Clin. Pharmacol. Ther. 18, 377–90.CrossRefPubMedGoogle Scholar
  98. Williams, R. T. (1959). In: The Metabolism and Detoxification of Drugs, Toxic Substances and Other Organic Compounds. Wiley, New York.Google Scholar

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