Excitotoxins pp 122-137 | Cite as

The Neurodegenerative Properties Of Intracerebral Quinolinic Acid And Its Structural Analog Cis-2,3-Piperidine Dicarboxylic Acid

  • Robert Schwarcz
  • William O. Whetsell
  • Alan C. Foster
Part of the Wenner-Gren Center International Symposium Series book series (WGS)

Abstract

Experiments using intracerebral injections in rodents of kainic (KA) or ibotenic (IBO) acid, two amino acids of plant and fungal origin, respectively, have led to the hypothesis that human neurodegenerative diseases, e.g. Huntington’s disease (HD) and temporal lobe epilepsy, may be related to a pathological overproduction of endogenous neuroexcitatory amino acids (Coyle et al., 1977; Divac, 1977; Olney and de Gubareff, 1978; French et al., 1982). Of these, glutamate, aspartate and cysteine sulfinate, all putative neurotransmitters in the central nervous system (Roberts et al., 1981; Recasens et al., 1982), do not appear to posses pronounced neurotoxicity, even when introduced into the brain at very high concentrations (Olney and de Gubareff, 1978; Mangano and Schwarcz, 1983). Also, examinations of acidic amino acids in tissues and body fluids of patients suffering from HD or epilepsy have merely yielded equivocal results (Perry et al., 1975; Gray et al., 1980; Perry and Hansen, 1981; Mangano and Schwarcz, 1981, 1982). Their dysfunction in neuro-psychiatric disorders has as yet not been established.

Keywords

Tryptophan Choline Pyrami Dinucleotide Nicotinic Acid 

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References

  1. Andersson, K., R. Schwarcz and K. Fuxe (1980): Nature, 283:94–96.CrossRefPubMedGoogle Scholar
  2. Ben-Ari, Y., J. Lagowska, E. Tremblay and G. Le Gal La Salle (1979): Brain Res., 163:176–180.CrossRefPubMedGoogle Scholar
  3. Ben-Ari, Y., E. Tremblay and O.P. Ottersen (1980): Neuroscience, 5:515–528.CrossRefPubMedGoogle Scholar
  4. Biziere, K. and J.T. Coyle (1978): Neurosci. Lett., 8:303–310.CrossRefPubMedGoogle Scholar
  5. Bruyn, G. (1968); In: Handbook of Clinical Neurology, Vol. 6 (P.J. Vinken and G. W. Bruyn, eds.), pp. 298–378, North-Holland, Amsterdam.Google Scholar
  6. Bull, G. and B. Oderfeld-Novak (1971): J. Neurochem., 19:935–947.CrossRefGoogle Scholar
  7. Campochiaro, P. and J.T. Coyle (1978); Proc. Natl. Acad. Sci. (USA), 75:2025–2029.Google Scholar
  8. Coyle, J.T. and R. Schwarcz (1976): Nature, 263:244–246.CrossRefPubMedGoogle Scholar
  9. Coyle, J.T., R. Schwarcz, J.P. Bennett and P. Campochiaro (1977): Progr. Neuro-Psychopharmac., 1:13–30.CrossRefGoogle Scholar
  10. Coyle, J.T., R. Zaczek, J. Slevin and J. Collins (1981): In: Glutamate as a Neurotransmitter (G. Di Chiara and G.L. Gessa, eds.), pp. 337–346, Raven, New York.Google Scholar
  11. Croucher, M.J., J.F. Collins and B.S. Meldrum (1982): Science, 216:899–901.CrossRefPubMedGoogle Scholar
  12. Di Chiara, G., M.L. Porceddu, W. Fratta and G.L. Gessa (1977): Nature, 267:270–272.CrossRefPubMedGoogle Scholar
  13. Divac, I. (1977): Acta Neurol. Scand., 56:357–360.CrossRefPubMedGoogle Scholar
  14. Fagg, E.G., A.C. Foster, E.E. Mena and C.W. Cotman (1982): J. Neurosci., 2:958–965.PubMedGoogle Scholar
  15. Falconer, M.A. (1974): Lancet, 2:767–770.CrossRefPubMedGoogle Scholar
  16. Foster, A.C. and P.J. Roberts (1978): J. Neurochem., 31:1476–1477.CrossRefGoogle Scholar
  17. French, E.D., C. Aldinio and R. Schwarcz (1982): Neuroscience, in press.Google Scholar
  18. Gal, E.M. (1974): J. Neurochem., 22:861–863.CrossRefPubMedGoogle Scholar
  19. Gal, E.M. and A.D. Sherman (1978): J. Neurochem., 30:607–613.CrossRefPubMedGoogle Scholar
  20. Gholson, R.K., I. Ueda, N. Ogasawa and L.M.Henderson (1964): J. Biol. Chem., 239: 1208–1214.Google Scholar
  21. Gray, P.N., P.C. May, L. Mundy and J. Elkins (1980): Biochem. Biophys. Res. Comm., 95:707–714.Google Scholar
  22. Hattori, T. and E.G. McGeer (1977): Brain Res., 129:174–180.CrossRefPubMedGoogle Scholar
  23. Henderson, L.M. and G.B. Ramasarma (1949): J. Biol. Chem., 181:687–692.Google Scholar
  24. Köhler. C. and R. Schwarcz (1981): Int. Soc. Neurochem. Abstr.. p. 272.Google Scholar
  25. Köhler, C., R. Schwarcz and K. Fuxe (1979a): Neurosci. Lett., 15:223–228.CrossRefPubMedGoogle Scholar
  26. Köhler, C., R. Schwarcz and K. Fuxe (1979b): Brain Res., 175:366–371.CrossRefPubMedGoogle Scholar
  27. König, J.F.R. and R.A. Klippel (1963): The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brainstem, Williams and Wilkins, Baltimore.Google Scholar
  28. Lapin, I.P. (1978): J. Neural Transm., 42:37–43.CrossRefPubMedGoogle Scholar
  29. Mangano, R.M. and R. Schwarcz (1981): J. Neurochem., 37:1072–1074.CrossRefPubMedGoogle Scholar
  30. Mangano, R.M. and R. Schwarcz (1982): J. Neurol. Sci., 53:489–500.Google Scholar
  31. Mangano, R.M. and R. Schwarcz (1983): Brain Res. Bull., in press.Google Scholar
  32. Maxwell, J.R. and P.D. Ray (1980): Biochim. Biophys. Acta, 614:163–172.Google Scholar
  33. McGeer, E.G. and P.L. McGeer (1976): Nature, 263:517–519.CrossRefPubMedGoogle Scholar
  34. McGeer, E.G., P.L. McGeer and K. Singh (1978): Brain Res., 139:381–383.CrossRefPubMedGoogle Scholar
  35. Mena, E.E., G.E. Fagg and C.W. Cotman (1982): Brain Res., 243:378–381.CrossRefPubMedGoogle Scholar
  36. Menini, C., B.S. Meldrum, D. Riche, C. Silva-Comte and J.M. Stutzmann (1980): Ann. Neurol., 8:501–509.CrossRefPubMedGoogle Scholar
  37. Nadler, J.V., D.A. Evenson and G.L. Cuthbertson (1981): Neuroscience, 6:2505–2517.CrossRefPubMedGoogle Scholar
  38. Nadler, J.V., B.W. Perry and C.W. Cotman (1978): Nature, 271:676–677.CrossRefPubMedGoogle Scholar
  39. Olney, J.W. (1978): In: Kainic Acid as a Tool in Neurobiology (E.G. McGeer, J.W. Olney and P.L. McGeer, eds.), pp. 95–121, Raven, New York.Google Scholar
  40. Olney, J.W. (1980): In: Experimental and Clinical Neurotoxicity (P.S. Spencer and H.H. Schaumburg, eds.), pp. 272–294, Williams and Wilkins, Baltimore.Google Scholar
  41. Olney, J.W. and T. de Gubareff (1978): Nature, 271:557–559.CrossRefPubMedGoogle Scholar
  42. Olney, J.W., O.H. Ho and V. Rhee (1971): Exp. Brain Res., 14:61–76.CrossRefPubMedGoogle Scholar
  43. Perry, T.L. and S. Hansen (1981): Neurobiology, 31:872–876.Google Scholar
  44. Perry, T.L., S. Hansen, J. Kennedy, J.A. Wada and G.B. Thompson (1975): Arch. Neurol., 32:752–754.CrossRefPubMedGoogle Scholar
  45. Recasens, M., T.V. Varga, D. Nanopoulos, F. Saadoun, G. Vincendon and J. Benavides (1982): Brain Res., 239:153–173.CrossRefPubMedGoogle Scholar
  46. Roberts, P.J., J. Storm-Mathisen and G.A.R. Johnston (1981): Glutamate: Transmitter in the Central Nervous System, Wiley, New York.Google Scholar
  47. Schwarcz, R., J.F. Collins and D.A. Parks (1982b): Neurosci. Lett., in press.Google Scholar
  48. Schwarcz, R. and J.T. Coyle (1977): Life Sci., 20:431–436.CrossRefPubMedGoogle Scholar
  49. Schwarcz, R. and K. Fuxe (1979): Life Sci., 24:1471–1480.CrossRefPubMedGoogle Scholar
  50. Schwarcz, R., T. Hökfelt, K. Fuxe, G. Jonsson, M. Goldstein and L. Terenius (1979): Exp. Brain Res., 37:199–216.CrossRefPubMedGoogle Scholar
  51. Schwarcz, R., D. Scholz and J.T. Coyle (1978a): Neuropharmac., 17:145–151.CrossRefGoogle Scholar
  52. Schwarcz, R., W.O. Whetsell, Jr. and R.M. Mangano (1982a): Science, in press. Schwarcz, R., R. Zaczek and J.T. Coyle (1978b): Europ. J. Pharmac., 50:209–220.Google Scholar
  53. Schwob, J.E., T. Fuller, J.L. Price and J.W. Olney (1980): Neuroscience, 5:991–1014.CrossRefPubMedGoogle Scholar
  54. Simon, J.R., J.F. Contrera and M.J. Kuhar (1976): J. Neurochem., 26:141–147.PubMedGoogle Scholar
  55. Stone, T.W. and M.N. Perkins (1981): Europ. J. Pharmac., 72:411–412.CrossRefGoogle Scholar
  56. Storm-Mathisen, J. (1977): Brain Res., 120:376–386.CrossRefGoogle Scholar
  57. Watkins, J.C. (1981): In: Glutamate: Transmitter in the Central Nervous System (P.J. Roberts, J. Storm-Mathisen and G.A.R. Johnston, eds.), pp. 1–25, Wiley, New York.Google Scholar
  58. Watkins, J.C. and R.H. Evans (1981): Ann. Rev. Pharmac. Toxic., 21:165–204.Google Scholar
  59. Waymire, J.C., R. Bjur and N. Weiner (1971): Anal. Biochem., 43:588–600.CrossRefPubMedGoogle Scholar
  60. Wuerthele, S.M., K.L. Lovell, M.Z. Jones and K.E. Moore (1978): Brain Res., 149: 489–497.CrossRefPubMedGoogle Scholar

Copyright information

© The Wenner-Gren Center 1983

Authors and Affiliations

  • Robert Schwarcz
    • 1
  • William O. Whetsell
    • 2
  • Alan C. Foster
    • 1
  1. 1.Maryland Psychiatric Research CenterUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Division of NeuropathologyUniversity of Tennessee Center of the Health SciencesMemphisUSA

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