Abstract
During the last decade the research activities in the field of antidepressants were to a great extent devoted to the development of drugs with selective actions on the uptake of norepinephrine (NE) or serotonin (5-HT). The expectations which were linked to the development of such drugs were manifold. It was hoped that they would represent true innovations by offering a more selective and efficaceous treatment of affective disorders. It was also assumed that these drugs would serve as useful means to test the validity of the current hypothesis, postulating causal relationships between NE and/or 5-HT disturbances and depression. Last, but not least, it was thought that such selective compounds could help to identify particular subpopulations of depressive patients and to clarify the general importance of NE and 5-HT in the regulation of higher nervous functions.
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Delini-Stula, A., Vassout, A., Hauser, K., Bittiger, H., Buech, U., Olpe, HR. (1983). Oxaprotiline and its enantiomers: do they open new avenues in the research on the mode of action of antidepressants?. In: Usdin, E., Goldstein, M., Friedhoff, A., Georgotas, A. (eds) Frontiers in Neuropsychiatric Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06689-6_9
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DOI: https://doi.org/10.1007/978-1-349-06689-6_9
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