Abstract
Although the beta-lactam antibiotics are by the far the most important therapeutic agents that act by inhibiting bacterial cell-wall peptidoglycan synthesis, several other totally unrelated antibiotics act at earlier stages of this essential pathway (Selwyn, 1980a). The clinically significant members of this miscellaneous group of drugs are bacitracin, vancomycin, cycloserine and phosphomycin. Others of less importance include novobiocin and ristocetin. The current position in relation to each can be briefly reviewed.
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References
Barker, B.M. and Prescott, F. (1973). Antimicrobial Agents in Medicine. Blackwell, Oxford.
Brown, A.G. (1981). New Naturally Occurring B-lactam Antibiotics and Related Compounds. J. antimicrob. Chemother., 7, 15–48.
Brown, R. and Wise, R. (1982). Vancomycin: a Reappraisal. Br. med. J., 284, 1508–1509.
Davies, A.J. (1982). New Antimicrobials. Br. J. hosp. Med., 27, 136–142.
Garrod, L.P., Lambert, H.P. and O’Grady, F. (1981). Antibiotic and Chemotherapy. Churchill Livingstone, Edinburgh and London.
Selwyn, S. (1976). Rational Choice of Penicillins and Cephalosporins Based on Parallel In-vitro and In-vivo Tests. Lancet, 2, 616–619.
Selwyn, S. (1979a). Pioneer Work on the ‘Penicillin Phenomenon’, 1870–1876. J. antimicrob. Chemother., 5, 249–255.
Selwyn, S. (1979b). The Development of a Hospital Antibiotic Policy in England. In Antibiotics and Hospitals. (eds. C. Grassi and G. Ostini). Alan R. Liss, New York.
Selwyn, S. (1980a). Mechanisms and Range of Activity of Penicillins and Cephalosporins. In The Beta-lactam Antibiotics: Penicillins and Cephalosporins in Perspective. Hodder and Stoughton, London.
Selwyn, S. (1980b). Discovery and Evolution of Penicillins and Cephalosporins. In The Beta-lactam Antibiotics: Penicillins and Cephalosporins in Perspective. Hodder and Stoughton, London.
Selwyn, S. (1980c). Clinical Compendium of Penicillins and Cephalosporins. In The Beta-lactam Antibiotics: Penicillins and Cephalosporins in Perspective. Hodder and Stoughton, London.
Selwyn, S. (1980d). Beta-lactamases in Practice. In The Beta-lactam Antibiotics: Penicillins and Cephalosporins in Perspective. Hodder and Stoughton, London.
Selwyn, S. (1980e). The Role of Beta-lactan Agents in Antibiotic Policies and Strategy. In The Beta-lactam Antibiotics: Penicillins and Cephalosporins in Perspective. Hodder and Stoughton, London.
Selwyn, S. (1981). The Topical Treatment of Skin Infections. In Skin Microbiology: Relevance to Clinical Infection. (eds. H.I. Maibach and R. Aly). Springer-Verlag. New York.
Selwyn, S. (1982). The Evolution of Broad Spectrum Penicillins. J. antimicrob. Chemother., 9, Supp1. B., 1–10.
Slocombe, B., Basker, M.J., Bentley, P.H., Clayton, J.P., Cole, M. Comber, K.R., Dixon, R.A., Edmondson, R.A., Jackson, D., Merrikin, D.J. and Sutherland, R. (1981). BRL 17421, a Novel β-lactam Antibiotic, Highly Resistant to β-lactamases, Giving High and Prolonged Serum Levels in Humans. Antimicrob. Agents Chemother., 20, 38–46.
Sykes, R.B. and Phillips, I. (1981). Azthreonam, a Synthetic Monobactam. J. antimicrob. Chemother., 8, Suppl. E.
Symposium (1977). Fosfomycin: Laboratory Studies. Chemother. 23, Suppl. 1.
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Selwyn, S. (1983). Antibiotics affecting microbial cell walls: Progress after 112 years. In: Edwards, D.I., Hiscock, D.R. (eds) Chemotherapeutic Strategy. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06540-0_4
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DOI: https://doi.org/10.1007/978-1-349-06540-0_4
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