Abstract
In view of the efficacy of SAM reported in its clinical use in various pathologies (Agnoli et al. , 1976; Salvadorini et al. , 1980; Fiaccadori, 1981) we became interested to approach the problem of the in vivo metabolism of the compound. To this purpose S-adenosyl-L-[1-14C]methionine (1-14C-SAM), S-adenosyl-L- [3,4-14c] methionine (3,4-14C-SAM), or S-adenosyl-L-[methyl-14C]methionine (14CH3-SAM) was administered to rats by i.v. injection either at the specific radioactivity of the commercial material (trace dose) or mixed with unlabelled SAM.
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References
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Galli-Kienle, M., Giulidori, P., Catto, E., Stramentinoli, G. (1982). Metabolism of exogenously administered SAM. In: Biochemistry of S-Adenosylmethionine and Related Compounds. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06343-7_83
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DOI: https://doi.org/10.1007/978-1-349-06343-7_83
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-06345-1
Online ISBN: 978-1-349-06343-7
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