Metabolism of exogenously administered SAM
In view of the efficacy of SAM reported in its clinical use in various pathologies (Agnoli et al. , 1976; Salvadorini et al. , 1980; Fiaccadori, 1981) we became interested to approach the problem of the in vivo metabolism of the compound. To this purpose S-adenosyl-L-[1-14C]methionine (1-14C-SAM), S-adenosyl-L- [3,4-14c] methionine (3,4-14C-SAM), or S-adenosyl-L-[methyl-14C]methionine (14CH3-SAM) was administered to rats by i.v. injection either at the specific radioactivity of the commercial material (trace dose) or mixed with unlabelled SAM.
KeywordsSpecific Radioactivity Label Compound Methyl Carbon Homoserine Lactone Commercial Material
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