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Metabolism of exogenously administered SAM

  • Marzia Galli-Kienle
  • Paolo Giulidori
  • Emilia Catto
  • Giorgio Stramentinoli

Abstract

In view of the efficacy of SAM reported in its clinical use in various pathologies (Agnoli et al. , 1976; Salvadorini et al. , 1980; Fiaccadori, 1981) we became interested to approach the problem of the in vivo metabolism of the compound. To this purpose S-adenosyl-L-[1-14C]methionine (1-14C-SAM), S-adenosyl-L- [3,4-14c] methionine (3,4-14C-SAM), or S-adenosyl-L-[methyl-14C]methionine (14CH3-SAM) was administered to rats by i.v. injection either at the specific radioactivity of the commercial material (trace dose) or mixed with unlabelled SAM.

Keywords

Specific Radioactivity Label Compound Methyl Carbon Homoserine Lactone Commercial Material 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© The contributors 1982

Authors and Affiliations

  • Marzia Galli-Kienle
    • 1
  • Paolo Giulidori
    • 2
  • Emilia Catto
    • 2
  • Giorgio Stramentinoli
    • 1
  1. 1.Institute of ChemistrySchool of Medicine, University of MilanUnited Kingdom
  2. 2.Bio Research CoResearch LaboratoriesLiscateItaly

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