Metabolism of exogenously administered SAM
In view of the efficacy of SAM reported in its clinical use in various pathologies (Agnoli et al. , 1976; Salvadorini et al. , 1980; Fiaccadori, 1981) we became interested to approach the problem of the in vivo metabolism of the compound. To this purpose S-adenosyl-L-[1-14C]methionine (1-14C-SAM), S-adenosyl-L- [3,4-14c] methionine (3,4-14C-SAM), or S-adenosyl-L-[methyl-14C]methionine (14CH3-SAM) was administered to rats by i.v. injection either at the specific radioactivity of the commercial material (trace dose) or mixed with unlabelled SAM.
KeywordsHPLC Depression Creatinine Cysteine Carboxyl
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