Alkyltransferases: Mechanistic studies and mechanism-based specific inhibitors
This article will present a brief overview of mechanistic studies of reactions at sp3-hybridized carbon, both enzymecatalyzed and related non-enzymic model systems. These mechanistic studies lead to a description of transition state structure for the reactions under investigation, and thus are critical to the design of potent and specific inhibitors of this class of enzymes. The reactions under consideration are shown in eq. 1 and 2.
KeywordsTransition State Structure Methyl Transfer Steric Constraint Sulfonium Salt Sulfonium Compound
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