Relation between polyamine level and nucleic acid methylation in vivo

  • W Kersten
  • M Mach


Polyamines are essential in pro- and eukaryots for optimal growth and cell development. These organic cations associate with nucleic acids and proteins and stimulate the synthesis of DNA and RNA. Addition of spermine, spermidine or putrescine increased severalfold the specific activity and extent of methylation of E.coli tRNA by methyltransferases from rat tissues (Leboy, 1970). The question was therefore raised as to whether the observed effects of polyamines on the methylation of tRNA in vitro might reflect a functional role of polyamines on tRNA methylation invivo.


Organic Cation Polyamine Level Cellular Slime Mold Slime Mold Dictyostelium Discoideum Methylase Activity 
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© The contributors 1982

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  • W Kersten
  • M Mach

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