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Relation between polyamine level and nucleic acid methylation in vivo

  • W Kersten
  • M Mach

Abstract

Polyamines are essential in pro- and eukaryots for optimal growth and cell development. These organic cations associate with nucleic acids and proteins and stimulate the synthesis of DNA and RNA. Addition of spermine, spermidine or putrescine increased severalfold the specific activity and extent of methylation of E.coli tRNA by methyltransferases from rat tissues (Leboy, 1970). The question was therefore raised as to whether the observed effects of polyamines on the methylation of tRNA in vitro might reflect a functional role of polyamines on tRNA methylation invivo.

Keywords

Organic Cation Polyamine Level Cellular Slime Mold Slime Mold Dictyostelium Discoideum Methylase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The contributors 1982

Authors and Affiliations

  • W Kersten
  • M Mach

There are no affiliations available

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