Regulation of intracellular enzyme proteolysis by small-molecule cofactors
For the past five years our laboratory has studied the regulation of synthesis and degradation of phenylethanolamine N-methyltransferase, dopamine β-hydroxylase, and hydroxyindole O-methyltransferase, three enzymes involved in biogenic amine metabolism. Certain features of the regulation of these enzymes have been strikingly similar, despite the different metabolic functions they carry out. This has led us to speculate about common modes of turnover regulation which the enzymes might share.
KeywordsProline Lysine Trypsin Dexamethasone Norepinephrine
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