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Regulation of intracellular enzyme proteolysis by small-molecule cofactors

  • Roland D. Ciaranello

Abstract

For the past five years our laboratory has studied the regulation of synthesis and degradation of phenylethanolamine N-methyltransferase, dopamine β-hydroxylase, and hydroxyindole O-methyltransferase, three enzymes involved in biogenic amine metabolism. Certain features of the regulation of these enzymes have been strikingly similar, despite the different metabolic functions they carry out. This has led us to speculate about common modes of turnover regulation which the enzymes might share.

Keywords

Intracellular Protease Ornithine Aminotransferase Enzyme Proteolysis Adrenal Glucocorticoid Proteolytic Breakdown 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Roland D. Ciaranello
    • 1
  1. 1.Laboratory of Developmental Neurochemistry, Child Psychiatry Division Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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