3-Substituted-4-methoxy-5-hydroxybenzaldehydes and benzoic acids as inhibitors of catechol-O-methyltransferase

  • Ronald T. Borchardt
  • Joan A. Huber


The extraneuronal inactivation of catecholamines and the detoxification of many xenobiotic catechols are dependent upon the enzyme catechol-O-methyltransferase (COMT, EC COMT is a soluble, magnesium-requiring enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to a catechol substrate resulting in the formation of the meta and para-O-methylated products (Borchardt, 1980).


Benzoic Acid Sulfhydryl Group COMT Activity Benzaldehyde Derivative Catechol Substrate 
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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Ronald T. Borchardt
    • 1
  • Joan A. Huber
    • 1
  1. 1.Department of BiochemistryUniversity of KansasLawrenceUnited Kingdom

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