Abstract
The extraneuronal inactivation of catecholamines and the detoxification of many xenobiotic catechols are dependent upon the enzyme catechol-O-methyltransferase (COMT, EC 2.1.1.6). COMT is a soluble, magnesium-requiring enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to a catechol substrate resulting in the formation of the meta and para-O-methylated products (Borchardt, 1980).
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References
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Borchardt, R.T., Huber, J.A. (1981). 3-Substituted-4-methoxy-5-hydroxybenzaldehydes and benzoic acids as inhibitors of catechol-O-methyltransferase. In: Usdin, E., Weiner, N., Youdim, M.B.H. (eds) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06276-8_71
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DOI: https://doi.org/10.1007/978-1-349-06276-8_71
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-06278-2
Online ISBN: 978-1-349-06276-8
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