Advertisement

Models of Complex Host-Parasite Relationships: Murine Leishmaniasis

  • D. J. Bradley
Chapter

Abstract

In few human infections is there a greater diversity of disease patterns than in leishmaniasis, and the slow course of infection allows time for detailed examination of each type of disease. The visceral forms of leishmaniasis vary from transient subclinical infections to lethal disease affecting many organs. Cutaneous leishmaniasis comprises the classical chronic ‘Delhi sore’, diffuse infections resembling lepromatous leprosy, post-kala-azar dermal leishmanoid, the ‘recidiva’ lesions, and Chiclero ulcer, as well as the multiple skin lesions seen in parts of South America. Mucocutaneous lesions, again, are very diverse, though histologically less varied than the skin lesions.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blackwell, J., Freeman, J. and Bradley, D. (1980). Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice. Nature, Lond., 283, 72–4CrossRefGoogle Scholar
  2. Bradley, D. J. (1977). Regulation of Leishmania populations within the host. II. Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clin. exp. Immun., 30, 130–40Google Scholar
  3. Bradley, D. J. (1979). Regulation of Leishmania populations within the host. IV. Parasite and host cell kinetics studied by radioisotope labelling. Acta trop., 36, 171–9Google Scholar
  4. Bradley, D. J. and Kirkley, J. (1972). Variation in susceptibility of mouse strains to Leishmania donovani infection. Trans. R. Soc. trop. Med. Hyg., 66, 527–8CrossRefGoogle Scholar
  5. Bradley, D. J. and Kirkley, J. (1977). Regulation of Leishmania populations within the host. I. The variable course of Leishmania donovani infections in mice. Clin. exp. Immun., 30, 119–29Google Scholar
  6. Bradley, D. J., Taylor, B. A., Blackwell, J., Evans, E. P. and Freeman, J. (1979). Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin. exp. Immun., 37, 7–14Google Scholar
  7. Bryceson, A. D. M., Bray, R. S., Wolstencroft, R. A. and Dumonde, D. C. (1970). Immunity in cutaneous leishmaniasis of the guinea-pig. Clin. exp. Immun., 7, 301–41Google Scholar
  8. Gowen, J. W. (1960). Genetic effects in non-specific resistance to infectious diseases. Bact. Rev., 24, 192–200Google Scholar
  9. Howard, J. G., Hale, C. and Liew, F. Y. (1980a). Immunological regulation of experimental cutaneous leishmaniasis. I. Immunogenetic aspects of susceptibility to Leishmania tropica in mice. Parasite Immun., 2, 303–14CrossRefGoogle Scholar
  10. Howard, J. G., Hale, C. and Liew, F. Y. (1980b). Immunological regulation of experimental cutaneous leishmaniasis. III. The nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. J. exp. Med., 152, 594–607CrossRefGoogle Scholar
  11. Laveran C. L. A. (1912). Infections des souris et des rats dues au Kala-azar mediterraneen et au Kala-azar indien. Bull. Soc. Path. exot., 5, 715–21Google Scholar
  12. Laveran C. L. A. and Pettit, A. (1909) Infections experimentales legeres du rat et de la souris par la Leishmania donovani. C.r. Séanc. Soc. Biol., 66, 911–3Google Scholar
  13. Plant, J. and Glynn, A. A. (1979). Locating salmonella resistance gene on mouse chromosome. I. Clin. exp. Immun., 37, 1–6Google Scholar
  14. Stauber, L. A. (1958). Host resistance to the Khartoum strain of Leishmania donovani. Rice Inst. Pamph., 45, 80–96Google Scholar
  15. Stauber, L. A., McConnell, E. and Hoogstraal, H. (1966). Leishmaniasis in the Sudan Republic. 25. Experimental visceral leishmaniasis in the Nile grass rat, Arvicanthus niloticus niloticus Dollman. Expl Parasit., 18, 35–40CrossRefGoogle Scholar
  16. Webster, T. (1933). Inherited and acquired factors in resistance to infection. J. exp. Med., 57, 793–843CrossRefGoogle Scholar
  17. Yakimov, V. L. and Kol-Yakimova, N. K. (1912). Infections des souris blanches par les cultures de Leishmania infantum. Bull. Soc. Path. exot., 5, 218–20Google Scholar

Copyright information

© The contributors 1982

Authors and Affiliations

  • D. J. Bradley
    • 1
  1. 1.Ross Institute of Tropical HygieneLondon School of Hygiene and Tropical MedicineLondonUK

Personalised recommendations