Models of Complex Host-Parasite Relationships: Murine Leishmaniasis
In few human infections is there a greater diversity of disease patterns than in leishmaniasis, and the slow course of infection allows time for detailed examination of each type of disease. The visceral forms of leishmaniasis vary from transient subclinical infections to lethal disease affecting many organs. Cutaneous leishmaniasis comprises the classical chronic ‘Delhi sore’, diffuse infections resembling lepromatous leprosy, post-kala-azar dermal leishmanoid, the ‘recidiva’ lesions, and Chiclero ulcer, as well as the multiple skin lesions seen in parts of South America. Mucocutaneous lesions, again, are very diverse, though histologically less varied than the skin lesions.
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