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Schistosomiasis in the Immunosuppressed Host: Studies on the Host-Parasite Relationship of Schistosoma mansoni and S. bovis in T-cell-deprived and Hydrocortisone-treated Mice

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Animal Models in Parasitology

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Abstract

Approximately 20 years ago crucial experiments were performed to demonstrate the role of the thymus in the acquisition of the potential to respond to nearly all immunological stimuli (Miller, 1961; Good et al., 1962; Jankovic et al., 1962). Since that time T-cell-deprived animals, rendered so by neonatal thymectomy (as in the earliest experiments), or more conveniently by adult thymectomy, and total body irradiation (Miller et al., 1963) or by congenital thymic aplasia (Pantelouris, 1968), have been very widely used to study the interface between infectious agents and immunological defence mechanisms.

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Authors and Affiliations

  1. Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans, Herts, UK

    M. Doenhoff, R. Harrison, A. Sabah, H. Murare, D. Dunne & O. Hassounah

Authors
  1. M. Doenhoff
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  2. R. Harrison
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  3. A. Sabah
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  4. H. Murare
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  5. D. Dunne
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  6. O. Hassounah
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Editors and Affiliations

  1. MRC Laboratory Animals Centre, Carshalton, Surrey, UK

    Dawn G. Owen

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Doenhoff, M., Harrison, R., Sabah, A., Murare, H., Dunne, D., Hassounah, O. (1982). Schistosomiasis in the Immunosuppressed Host: Studies on the Host-Parasite Relationship of Schistosoma mansoni and S. bovis in T-cell-deprived and Hydrocortisone-treated Mice. In: Owen, D.G. (eds) Animal Models in Parasitology. Palgrave, London. https://doi.org/10.1007/978-1-349-06136-5_12

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