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Selective Inhibition of Sulfation in Vivo

  • Gerard J. Mulder
  • Ina C. M. Halsema
  • Henk Koster
  • John H. N. Meerman
  • K. Sandy Pang

Abstract

Sulfation is one of the most versatile conjugation reactions which accepts phenolic and alcoholic hydroxyl groups, hydroxamic acids and amines as acceptor grouns for conjugation. In this chapter only the sulfation of low-molecular weight substances will be discussed; most likely, completely unrelated sulfotransferases are involved in the sulfation of macromolecules like proteins and glycosaminoglycans, or phospholipids. Further, there are no data as yet on the selective inhibition of sulfation of these types of substrates. Both endogenous and xenobiotic substrates are metabolized by a number of sulfotransferases (Roy, 1981; Jakoby et al., 1980); the resulting sulfate conjugates are usually rapidly excreted in urine or bile. The toxicity of the parent comoound is often lost after sulfate conjugation. Therefore, sulfation and other conjugation reactions have been considered to be detoxication reactions (Williams, 1947). However, in recent years it has become clear that in some cases sulfate conjugates are much more toxic than the parent compound.

Keywords

Hydroxamic Acid Perfusion Medium Conjugation Reaction Sulfate Conjugate Hepatotoxic Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Gerard J. Mulder
    • 1
    • 2
  • Ina C. M. Halsema
    • 1
    • 2
  • Henk Koster
    • 1
    • 2
  • John H. N. Meerman
    • 1
    • 2
  • K. Sandy Pang
    • 1
    • 2
  1. 1.Department of PharmacologyState University of GroningenGroningenThe Netherlands
  2. 2.Department of PharmaceuticsUniversity of HoustonHoustonUSA

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