Abstract
Measurement of cerebrospinal fluid (CSF) constituents is the most direct approach available for study of cerebral neurotransmitter release and turnover in man. Numerous studies have demonstrated that neurotransmitter amines and their metabolites in CSF derive from the central nervous system and not from peripheral tissues (Pletscher et al., 1967; Moir et al., 1970; Garelis et al., 1974). CSF amine metabolite concentrations have also been shown to reflect neuronal aminergic activity in adjacent brain structures (Portig and Vogt, 1969; Moir et al., 1970; Papeschi et al., 1971). Because sensitive fluorometric methods have been available for measuring homovanillic acid (HVA), the major metabolite of dopamine, there have been numerous studies of lumbar CSF concentrations of HVA in patients with psychiatric or neurological disorders (for reviews, see Wood, 1980). Due to the presence of mediated transport systems for removal of organic acids from CSF (Wolfson et al., 1974), there have been questions about the extent to which lumbar CSF acid metabolite concentrations reflect cerebral aminergic activity. The nigrostriatal dopaminergic pathway, which is important in regulation of movement, terminates in the caudate nuclei directly adjacent to the lateral ventricles.
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Sharpless, N.S., Tyce, G.M., Thal, L.J., Waltz, J.M., Tabaddor, K., Wolfson, L.I. (1981). Conjugated Dopamine in Human Ventricular Fluid. In: Sandler, M., Usdin, E. (eds) Phenolsulfotransferase in Mental Health Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06118-1_12
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DOI: https://doi.org/10.1007/978-1-349-06118-1_12
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