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Sleep Studies in Clinical Pharmacology

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Abstract

Prescriptions for drugs that alter sleep are, with those for antibiotics, the commonest prescriptions of clinical practice. Some drugs that alter sleep are intended so to do and others, prescribed in the hope of altering mood, will generally alter sleep too, while yet others, prescribed for somatic ailments, may have unsuspected effects on the brain observable during sleep. I shall below take as a primary example the study in man of a drug expected to have hypnotic actions, following studies in animals and preliminary human testing.

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References

  • ADAM, K. (1979). Do drugs alter the restorative value of sleep? In Pharmacology of the States of Alertness, ed. Passouant, P. & Oswald, I., pp. 105–111. Oxford: Pergamon Press.

    Google Scholar 

  • ADAM, K., ADAMSON, L., BREZINOVÁ, V., HUNTER, W.M. & OSWALD, I. (1976a). Nitrazepam: lastingly effective but trouble on withdrawal. Br. med. J., 1, 1558–1560.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • ADAM, K., ADAMSON, L., BREZINOVA, V. & OSWALD, I. (1976b). Do placebos alter sleep? Br. med. J., 1, 195–196.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • ADAM, K. & OSWALD, I. (1979). One gram of L-tryptophan fails to alter the time taken to fall asleep. Neuropharmac., 18, 1025–1027.

    Article  CAS  Google Scholar 

  • AKINDELE, M.O., EVANS, J.I. & OSWALD, I. (1970). Monoamine oxidase inhibitors, sleep and mood. Electroenceph. clin. Neurophysiol., 29, 47–56.

    Article  PubMed  CAS  Google Scholar 

  • ALLEN, S. & OSWALD, I. (1976). Anxiety and sleep after fosazepam. Br. J. clin. Pharmac., 3, 165–168.

    Article  CAS  Google Scholar 

  • BIXLER, E.O., KALES, A., SOLDATOS, C.R., SCHARF, M.B. & KALES, J.D. (1978). Effectiveness of temazepam with short-, intermediate-, and long-term use: sleep laboratory evaluation. J. clin. Pharmac., 18, 110–118.

    Article  CAS  Google Scholar 

  • BOND, A. & LADER, M. (1974). The use of analogue scales in rating subjective feelings. Br. J. med. Psychol., 47, 211–218.

    Article  Google Scholar 

  • BONNET, M.H. & WEBB, W.B. (1979). The return to sleep. Biol. Psychol., 8, 225–233.

    Article  PubMed  CAS  Google Scholar 

  • BREBBIA, D.R. & ALTSHULER, K.Z. (1968). Stage related patterns and nightly trends of energy exchange during sleep. In Computers and Electronic Devices in Psychiatry, ed. Kline, N.S. & Laska, E., pp. 319–335. New York: Grune & Stratton.

    Google Scholar 

  • BREZINOVA, V. (1974). Effect of caffeine on sleep: EEG study in late middle aged people. Br. J. clin. Pharmac., 1, 203–208.

    Article  CAS  Google Scholar 

  • CARSKADON, M.A., DEMENT, W.C., MITLER, M.M., GUILLEMINAULT, C., ZARCONE, V.P. & SPIEGEL, R. (1976). Self-reports versus sleep laboratory findings in 122 drug-free subjects with complaints of chronic insomnia. Am. J. Psychiat., 133, 1382–1388.

    Article  PubMed  CAS  Google Scholar 

  • CASTLEDEN, C.M., GEORGE, C.F., MARCER, D. & HALLETT, C. (1977). Increased sensitivity to nitrazepam in old age. Br. med. J., 1, 10–12.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • CROWLEY, T.J. & HYDINGER-MACDONALD, M. (1979). Bedtime flurazepam and the human circadian rhythm of spontaneous motility. Psychopharmacology, 62, 157–161.

    Article  PubMed  CAS  Google Scholar 

  • DUNLEAVY, D.L.F., BREZINOVÁ, V., OSWALD, I., MACLEAN, A.W. & TINKER, M. (1972). Changes during weeks in effects of tricyclic drugs on the human sleeping brain. Br. J. Psychiat., 120, 663–672.

    Article  CAS  Google Scholar 

  • DUNLEAVY, D.L.F., MACLEAN, A.W. & OSWALD, I. (1971). Debrisoquine, guanethidine, propranolol and human sleep. Psychopharmacologia (Berl.) 21,101–110.

    Article  CAS  Google Scholar 

  • FRANKEL, B.L., COURSEY, R.D., BUCHBINDER, R. & SNYDER, F. (1976). Recorded and reported sleep in chronic primary insomnia. Arch. gen. Psychiat., 33, 615–623.

    Article  PubMed  CAS  Google Scholar 

  • GAILLARD, J.M. & AUBERT, C. (1975). Specificity of benzodiazepines action on human sleep confirmed. Another contribution of automtic analysis of polygraphic recordings. Biol. Psychiat., 10, 185–197.

    CAS  Google Scholar 

  • GREENBLATT, D.J., ALLEN, M.D. & SHADER, R.I. (1977). Toxicity of high-dose flurazepam in the elderly. Clin. Pharmac. Ther., 21, 355–361.

    CAS  Google Scholar 

  • HAIDER, I. & OSWALD, I. (1970). Late brain recovery processes after drug overdose. Br. med. J., 2, 318–322.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • HAIDER, I. & OSWALD, I. (1971). Effects of amylobarbitone and nitrazepam on the electrodermogram and other features of sleep. Br. J. Psychiat., 118, 519–522.

    Article  CAS  Google Scholar 

  • HINDMARCH, I. (1980). Psychomotor function and psychoactive drugs. Br. J. clin. Pharmac., 10, 189–210.

    Article  CAS  Google Scholar 

  • HINDMARCH, I., PARROTT, A.C. & ARENILLAS, L. (1977). A repeated dose comparison of dichloralphenazone, flunitrazepam and amylobarbitone sodium on some aspects of sleep and early morning behaviour in normal subjects. Br. J. clin. Pharmac., 4, 229–233.

    Article  CAS  Google Scholar 

  • JOHNS, M.W. (1977). Validity of subjective reports of sleep latency in normal subjects. Ergonomics, 20, 683–690.

    Article  PubMed  CAS  Google Scholar 

  • JOHNSON, L.C., HANSON, K. & BICKFORD, R.G. (1976). Effect of flurazepam on sleep spindles and K-complexes. Electroenceph. clin. Neurophysiol., 40, 67–77.

    Article  PubMed  CAS  Google Scholar 

  • JOHNSON, L.C., SEALES, D.M., NAITOH, P., CHURCH, M.W. & SINCLAIR, M. (1979). The effects of flurazepam hydrochloride on brain electrical activity during sleep. Electroenceph. clin. Neurophysiol., 47, 309–321.

    Article  PubMed  CAS  Google Scholar 

  • KALES, A., SCHARF, M.B. & KALES, J.D. (1978). Rebound insomnia: a new clinical syndrome. Science, 201, 1039–1041.

    Article  PubMed  CAS  Google Scholar 

  • KAY, D.C., BLACKBURN, A.B., BUCKINGHAM, J.A. & KARACAN, I. (1976). Human pharmacology of sleep. In Pharmacology of Sleep, ed. Williams, R.L. & Karacan, I., pp. 83–210. New York: John Wiley.

    Google Scholar 

  • LEWIS, S.A., OSWALD, I. & DUNLEAVY, D.L.F. (1971). Chronic fenfluramine administration: some cerebral effects. Br. med. J., 3, 67–70.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • OGUNREMI, O.O., ADAMSON, L., BREZINOVÁ, V., HUNTER, W.M., MACLEAN, A.W., OSWALD, I. & PERCY-ROBB, I.W. (1973). Two anti-anxiety drugs: a psychoneuroendocrine study. Br. med. J., 2, 202–205.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • OSWALD, I. (1970). Dependence upon hypnotic and sedative drugs. Br. J. hosp. Med., 4, 168–172.

    Article  Google Scholar 

  • OSWALD, I., ADAM, K., BORROW, S. & IDZIKOWSKI, C. (1979). The effects of two hypnotics on sleep, subjective feelings and skilled performance. In Pharmacology of the States of Alertness, ed. OSWALD, I., ADAM, K., BORROW, S. & IDZIKOWSKI, C., pp. 51–63. Oxford, Pergamon Press.

    Google Scholar 

  • OSWALD, I., LEWIS, S.A., DUNLEAVY, D.L.F., BREZINOVÁ, V. & BRIGGS, M. (1971). Drugs of dependence though not of abuse: fenfluramine and imipramine. Br. med. J., 3, 70–73.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • RECHTSCHAFFEN, A. & KALES, A. (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, D.C.: U.S. Government Printing Office, NIH Publication, No. 204.

    Google Scholar 

  • SALETU, B., ALLEN, M. & ITIL, T.M. (1974). The effect of coca-cola, caffeine, antidepressants, and chlorpromazine on objective and subjective sleep parameters. Pharmakopsychiat., 254, 307–321.

    Article  Google Scholar 

  • SAVIN, J. A., PATERSON, W.D., ADAM, K. & OSWALD, I. (1979). Effects of trimeprazine and trimipramine on noctural scratching in patients with atopic eczema. Arch. Dermatol., 115, 313–315.

    Article  PubMed  CAS  Google Scholar 

  • SPIEGEL, R. (1973). Controlled clinical investigations with a phenothiazine derivative used as sleep-inducer in non-psychotic insomniacs. In Sleep: Physiology, Biochemistry, Psychology, Pharmacology, Clinical Implications, ed. Koella, W.P. & Levin, P., pp. 91–101. Basel: Karger.

    Google Scholar 

  • TANSELLA, C.Z., TANSELLA, M. & LADER, M. (1979). A comparison of the clinical and psychological effects of diazepam and amylobarbitone in anxious patients. Br. J. clin. Pharmac., 7, 605–611.

    Article  CAS  Google Scholar 

  • WILLIAMS, H.L., MORLOCK, H.C., & MORLOCK, J.V. (1966). Discriminative responses to auditory signals during sleep. Psychophysiol., 2, 208–215.

    Article  CAS  Google Scholar 

  • ZEALLEY, A.K. & AITKEN, R.C.B. (1969). Measurement of mood. Proc. roy. Soc. Med., 62, 993–996.

    PubMed  CAS  PubMed Central  Google Scholar 

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M. H. Lader A. Richens

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© 1981 Palgrave Macmillan, a division of Macmillan Publishers Limited

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Oswald, I. (1981). Sleep Studies in Clinical Pharmacology. In: Lader, M.H., Richens, A. (eds) Methods in Clinical Pharmacology—Central Nervous System. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06038-2_4

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