Molecular Aspects of the Interaction between Quinoxaline Antibiotics and Nucleic Acids

  • Michael J. Waring
  • Keith R. Fox
Part of the Topics in Molecular and Structural Biology book series (TMSB)


Quinoxaline antibiotics are of widespread occurrence in nature. They are produced by a variety of species of streptomycetes and are characterised by an octadepsipeptide ring to which are attached two moieties of quinoxaline-2-carboxylic acid, hence their name. They were first isolated in the 1950s (see Katagiri et al., 1975 for a full description) and the best-known member of the group is echinomycin (Corbaz et al., 1957; Keller-Schierlein et al., 1959) whose structure, shown in figure 1, was recently revised.


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© The Contributors 1983

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  • Michael J. Waring
  • Keith R. Fox

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