Catecholaminergic Enzymes in Parkinson’s Disease and Related Extrapyramidal Diseases
The observation on the decrease in dopamine(Ehringer and Hornykiewicz, 1960) and in aromatic L-amino acid decarboxylase activity with DOPA as a substrate (DOPA decarboxylase activity) (Lloyd and Hornykiewicz, 1970) in the dopaminergic regions of the parkinsonian brain indicated the disturbance in dopamine biosynthesis.
KeywordsTyrosine Hydroxylase Locus Coeruleus Tardive Dyskinesia Parkinsonian Patient Dopa Decarboxylase
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