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Catecholaminergic Enzymes in Parkinson’s Disease and Related Extrapyramidal Diseases

  • Toshiharu Nagatsu
  • Kazuhiro Oka
  • Toshifumi Yamamoto
  • Hiroaki Matusui
  • Takeshi Kato
  • Chosaburo Yamamoto
  • Ikuko Nagatsu
  • Reiji Iizuka
  • Hirotaro Narabayashi

Abstract

The observation on the decrease in dopamine(Ehringer and Hornykiewicz, 1960) and in aromatic L-amino acid decarboxylase activity with DOPA as a substrate (DOPA decarboxylase activity) (Lloyd and Hornykiewicz, 1970) in the dopaminergic regions of the parkinsonian brain indicated the disturbance in dopamine biosynthesis.

Keywords

Tyrosine Hydroxylase Locus Coeruleus Tardive Dyskinesia Parkinsonian Patient Dopa Decarboxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© The Contributors 1981

Authors and Affiliations

  • Toshiharu Nagatsu
    • 1
  • Kazuhiro Oka
    • 1
  • Toshifumi Yamamoto
    • 1
  • Hiroaki Matusui
    • 2
  • Takeshi Kato
    • 1
  • Chosaburo Yamamoto
    • 2
  • Ikuko Nagatsu
    • 3
  • Reiji Iizuka
    • 4
  • Hirotaro Narabayashi
    • 5
  1. 1.Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School of NagatsutaTokyo Institute of TechnologyYokohamaJapan
  2. 2.Department of Physiology, Faculty of MedicineKanazawa UniversityKanazawaJapan
  3. 3.Department of Anatomy, School of MedicineFujita-Gakuen UniversityTayoakeJapan
  4. 4.Department of Psychiatry, School of MedicineJuntendo UniversityTokyoJapan
  5. 5.Department of Neurology, School of MedicineJuntendo UniversityTokyoJapan

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