Abstract
Certain criteria should be satisfied to establish that a given drug exerts its effects by interactions with a specific neurotransmitter receptor (NTR). The first of these criteria is that the radiolabeled drug binding sites show selectivity similar to the known pharmacology of that NTR. Additional criteria include: 1) a correlation between ligand selectivity at drug binding sites and radiolabeled neurotransmitter sites, 2) evidence that the drug mimics or antagonizes an agonist mediated physiological event at that NTR, and 3) physicochemical identity of purified drug binding sites and the NTR. Based on these criteria, the investigation of the NTR involved in antipsychotic ligand action is in the preliminary stages.
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Andorn, A.C. (1981). Antipsychotic Ligand Binding Sites in the Human Brain: Regional Selectivity Implicates Involvement of Multiple Neurotransmitters. In: Riederer, P., Usdin, E. (eds) Transmitter Biochemistry of Human Brain Tissue. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05932-4_14
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DOI: https://doi.org/10.1007/978-1-349-05932-4_14
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