Radioreceptor binding technique as aid in treatment with neuroleptics
In all medicinal treatment efforts must be made to find the optimal dose for each patient separately. Both therapeutic effects and adverse effects may occur at doses differing widely from one individual to another. Furthermore, the use of a given dose of a drug may perhaps result in the blood concentration of the drug being anything up to 30 times higher in one patient than in another (Hammer and Sjöqvist, 1967; Forsman and Öhman, 1975; Axelsson and Mårtensson, 1976). It is possible to ascertain the optimal dosage level or range of several drugs, that is the dose producing a maximum effect with a minimum of side effects. By adjusting the dose of a drug according to its concentration in the serum, for example, it has proved possible to improve the effect of the drug and to minimize its side effects. But it has so far not been possible to establish a generally applicable concentration range for neuroleptics. This failure has been ascribed, first, to the fact that most neuroleptics are transformed to a series of active metabolites. One can therefore not a priori expect the clinical picture to vary solely with the blood concentration of the drug, which is only one of the active substances. Second, it has become increasingly clear that the response to a given concentration can vary from one patient to another. As far as neuroleptics are concerned, this variation may be due to a probably genetic variation of the susceptibility of the dopamine (DA) system.
KeywordsHigh Performance Liquid Chromatography Dopamine Schizophrenia Prolactin Haloperidol
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