Skip to main content

Neuroleptic-induced ‘tardive Tourrette’s syndrome’ and neurotoxicity

  • Chapter
Clinical Pharmacology in Psychiatry

Abstract

Neurological side effects have been associated with neuroleptic drugs since these drugs were introduced in the treatment of psychiatric disorders. Acute dystonia and parkinsonism may be seen in the initial phases of treatment while a hyperkinetic syndrome may develop later. Fauerby et al. (1964) named this late syndrome tardive dyskinesia. The frequent irreversibility of the syndrome may be regarded as a sign of a potential neurotoxic effect of neuroleptic drugs (Gerlach, 1979).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Christensen, A. V. and Møller-Nielsen, I. (1979). Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics and drugs used for the treatment of tardive dyskinesia. Psychopharmacology, 62, 111–6

    Article  PubMed  CAS  Google Scholar 

  • Clow, A., Theodorou, A., Jenner, P. and Marsden, C. D. (1980). Changes in rat striatal dopamine turnover and receptor activity during one year’s neuroleptic administration. Eur. J. Pharmac., 63, 135–44

    Article  CAS  Google Scholar 

  • Faurbye, A., Rasch, P. J., Petersen, P. B., Brandborg, G. and Pakkenberg, H. (1964). Neurological symptoms in pharmacotherapy of psychoses. Acta psychiat. scand., 40, 10–27

    Article  PubMed  CAS  Google Scholar 

  • Fog, R. and Pakkenberg, H. (1980). Theoretical and clinical aspects of theTourette syndrome (chronic multiple tic). J. neural Transmission, Suppl. 6, 211–5

    Google Scholar 

  • Fog, R., Pakkenberg, H., Nielsen, E. B., Munkvad, I., Lyon, M. and Randrup, A. (1980). Neurotoxic effects in rats of neuroleptic drugs. In Phenothiazines and Structurally Related Drugs — Basic and Clinical Studies (ed. E. Usdin, H. Eckert and I. Forrest), Elsevier North-Holland, New York

    Google Scholar 

  • Gerlach, J. (1979). Tardive dyskinesia. Dan. med. Bull., 26, 209–45

    PubMed  CAS  Google Scholar 

  • Nielsen, E. B. and Lyon, M. (1978). Evidence for cell loss in corpus striatum after long term treatment with a neuroleptic drug (flupenthixol) in rats. Psychopharmacology, 59, 85–9

    Article  PubMed  CAS  Google Scholar 

  • Pakkenberg, H., Fog, R. and Nilakantan, B. (1973). The long term effect of perphenazine enanthate on the rat brain. Some metabolic and anatomical observations. Psychopharmacologia 29, 329–36

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Copyright information

© 1981 The contributors

About this chapter

Cite this chapter

Fog, R., Pakkenberg, H. (1981). Neuroleptic-induced ‘tardive Tourrette’s syndrome’ and neurotoxicity. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_34

Download citation

Publish with us

Policies and ethics