Abstract
The tricyclic antidepressant drugs (TCA) are widely used in the treatment of depression. Since there are marked interindividual differences in the steady state concentrations of a TCA in plasma, the monitoring of the plasma concentrations as a guide to effective dosage has been developed. There are indications that both high and low concentrations of nortriptyline (NT), for example, are associated with poor clinical responses (Åsberg, 1974; Kragh-Sørensen et al., 1976), while the response may increase linearly with the plasma concentrations of imipramine and amitriptyline (AMI) (Gram, 1980).
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References
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Carroll, B.J., Mukhopadhyay, S., Feinberg, M. (1981). Radioimmunoassay of tricyclic antidepressants. In: Usdin, E., Dahl, S.G., Gram, L.F., Lingjærde, O. (eds) Clinical Pharmacology in Psychiatry. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05929-4_3
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DOI: https://doi.org/10.1007/978-1-349-05929-4_3
Publisher Name: Palgrave Macmillan, London
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Online ISBN: 978-1-349-05929-4
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