Abstract
Many hormones and neurotransmitters control the ionic permeability of the plasma membrane in their target cells. It has been proposed that membrane permeability responses are mediated by changes in cytosolic ionised calcium concentration (Petersen, 1976, 1980; Bülbring and Tomita, 1977; Putney, 1979). The pancreatic acini would appear to provide a good model for the study of the mechanisms underlying hormonal control of plasma membrane permeability. The mouse pancreatic acinar tissue consists of units of closely electrically coupled acinar cells. One unit comprises approximately 500 cells (Iwatsuki and Petersen, 1978c). In addition to electrical communication, organic molecules like procion yellow (molecular weight 697 daltons) can pass easily from cell to cell (Iwatsuki and Petersen, 1979). There is virtually no electrical coupling between pancreatic acinar units (Iwatsuki and Petersen, 1978c). Electrophysiological investigations with several intracellular microelectrodes and extra- and intracellular micro-application of drugs are feasible due to the thinness of the mouse pancreas, allowing easy visualisation of individual cells in the living tissue (Iwatsuki and Petersen, 1978c, 1979). The pancreatic acinar cells possess many different peptide hormone receptor sites in addition to cholinergic, muscarinic receptors. Some of the peptide receptors can activate adenylate cyclase, others can not (Gardner, 1979). The acinar plasma membrane contains specific Na-dependent amino acid transport mechanisms (Schulz and Ullrich, 1979) and it has recently been shown that several l-amino acids evoke membrane potential and resistance changes of a nature totally different from those evoked by the secretagogue peptides or acetylcholine (ACh) (Iwatsuki and Petersen, 1980).
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© 1981 Institute of Biology Endowment Trust Fund
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Petersen, O.H., Nishiyama, A., Laugier, R., Philpott, H.G. (1981). Hormonal control of ion permeability of the pancreatic acinar cell membrane mediated by intracellular calcium. In: Birdsall, N.J.M. (eds) Drug Receptors and Their Effectors. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-05555-5_7
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