Skip to main content

Transplantation of canine tumours into immunosuppressed dogs and nude mice

  • Chapter
Immunodeficient Animals for Cancer Research
  • 103 Accesses

Abstract

Many of the spontaneous malignant tumours which occur in the dog have a similar behaviour to their counterparts in man and are very valuable in comparative cancer studies. World Health Organisation international clinical trials on therapy of canine osteosarcoma, lymphosarcoma and mammary carcinoma, which are good ‘models’ for these conditions in man, are planned. There are, however, certain observations and investigations which can be better performed on dogs with transplanted tumours than in these clinical cases, and suitable methods of doing this in an outbred species have been achieved.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allam, M. W., Lombard, L. S., Stubbs, E. L. and Shirer, J. F. (1956). Transplantability of a canine thyroid carcinoma through thirty generations in mixed breed puppies. J. natn. Cancer Inst, 17, 123–9

    CAS  Google Scholar 

  • Bennett, B. T., Taylor, Y. and Epstein, R. (1975). Segregation of the clinical cause of transmissible venereal tumour with D.L.A. haplotypes in canine families. Transplantation Proc, 7, 503–5

    Google Scholar 

  • Betton, G. R. and Owen, L. N. (1976). Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs. Br. J. Cancer, 34, 374–80

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Campanile, F., Crino, L., Bonmasser, E., Houchens, D. and Goldin, A. (1977). Radioresistant inhibition of lymphoma growth in congenitally athymic (nude) mice. Cancer Res, 37, 394–8

    CAS  PubMed  Google Scholar 

  • Cohen, D. (1972). Detection of humoral antibody to the transmissible venereal tumour of the dog. int. J. Cancer, 10, 207–12

    Article  CAS  PubMed  Google Scholar 

  • Cohen, D. (1973). The biological behaviour of the transmissible venereal tumour in immunosuppressed dogs. Eur. J. Cancer, 9, 253–8

    Article  CAS  PubMed  Google Scholar 

  • Cohen, D. (1978). The transmissible venereal tumour of the dog-a naturally occurring allograft. A review. Israel J. med. Sci, 14, 14–19

    CAS  PubMed  Google Scholar 

  • Cohen, D. and Steel, G. G. (1972). Thymidine labelling studies in a transmissible venereal tumour of the dog. Br. J. Cancer, 26, 413–19

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Cohen, H., Chapman, A. L., Ebert, J. W., Boff, W. J. and Gravelle, C. R. (1970). Cellular transmission of canine lymphoma and leukaemia in Beagles. J. natn. Cancer Inst, 45, 1013–24

    CAS  Google Scholar 

  • Dennis, R. A., Jacoby, R. O. and Griesemer, F. A. (1969a). Development of immunity in fetal dogs. Skin allograft reaction. Am. J. vet. Res 30, 1511–6

    CAS  PubMed  Google Scholar 

  • Dennis, R. A., Jacoby, R. O. and Griesemer, F. A. (1969b). Development of immunity in fetal dogs. Effects of thymectomy. Am. J. vet. Res 30, 1517–72

    CAS  PubMed  Google Scholar 

  • Epstein, R. B. and Bennett, B. T. (1973). Transplantation immunology of canine venereal tumour. Clin. Res, 21, 876–9

    Google Scholar 

  • Epstein, A., Herman, M. M., Kim, H., Dorfman, R. F. and Kaplan, H. S. (1976). Biology of the human malignant lymphomas. III. Intracranial heterotransplantation in nude, athymic, mice. Cancer, 37, 2158–76

    Article  CAS  PubMed  Google Scholar 

  • Holmes, J. M. (1978). Aspects of an intranuclear isotope labelling technique for measuring tumour cell death in vivo and in vitro. PhD thesis, University of Cambridge

    Google Scholar 

  • Irvin, A. D., Brown, C. G. D., Kanhai, G. K. and Stagg, D. A. (1975). Comparative growth of bovine lymphosarcoma cells and lymphoid cells infected with Theileria parva in athymic (nude) mice. Nature, Lond, 255, 713–4

    Article  CAS  Google Scholar 

  • Irvin, A. D., Brown, C. G. D., Kanhai, G. K. and Stagg, D. A. (1977). Transplantation of bovine lymphosarcoma cells to athymic (nude) mice. Res. vet. Sci, 22, 53–5

    CAS  PubMed  Google Scholar 

  • Jacoby, R. O., Dennis, R. A. and Griesemer, R. A. (1969). Development of immunity in fetal dogs: humoral responses. Am. J. vet. Res, 30, 1503–10

    CAS  PubMed  Google Scholar 

  • Jacoby, R. O. and Griesemer, F. A. (1970). Immunologic injury to dogs. Adv. vet. Sci, 14, 150–87

    Google Scholar 

  • Moldovanu, G., Moore, A. E., Friedman, M. and Miller, D. G. (1966). Cellular transmission of lymphosarcoma in dogs. Nature, Lond, 210, 1342–3

    Article  CAS  Google Scholar 

  • Morgan, D. R., Owen, L. N. and Onions, D. E. (1978). Growth of canine lymphosarcoma in X-irradiated and non-irradiated athymic (nude) mice. Eur. J. Cancer, 14, 1453–7

    Article  Google Scholar 

  • Oughton, S. M. J. and Owen, L. N: (1974). Transplantation of dog neoplasms into the mouse mutant Nude. Res. vet. Sci 17, 414–6

    Google Scholar 

  • Owen, L. N. (1969). Transplantation of canine osteosarcoma. Eur. J. Cancer, 5, 615–20

    Article  CAS  PubMed  Google Scholar 

  • Owen, L. N., (1971). Serial transplantation of canine lymphocytic leukaemia. Eur. J. Cancer, 7, 525–8

    Article  CAS  PubMed  Google Scholar 

  • Owen, L. N. and Bostock, D. E. (1973). Prophylactic X-irradiation of the lung in canine tumours with particular reference to osteosarcoma. Eur. J. Cancer, 9, 747–52

    Article  CAS  PubMed  Google Scholar 

  • Owen, L. N. and Nielsen, S. W. (1968). Transplantation of canine lymphosarcoma. Eur. J. Cancer, 4, 391–3

    CAS  Google Scholar 

  • Owen, L. N. and Steel, G. G. (1969). The growth and cell population kinetics of spontaneous tumours in domestic animals. Br. J. Cancer, 23, 493–509

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Owen, L. N., Bostock, D. E. and Halliwell, R. E. W. (1975). Cell mediated and humoral immunity in dogs with spontaneous lymphosarcoma. Eur. J. Cancer, 11, 187–91

    Article  CAS  PubMed  Google Scholar 

  • Owen, L. N., Morgan, D. R., Bostock, D. E. and Flemans, R. J. (1977). Tissue culture and transplantation studies on canine mammary carcinoma. Eur. J. Cancer, 13, 1445–9

    Article  CAS  PubMed  Google Scholar 

  • Powers, R. D. (1968). Immunologic properties of canine transmissible venereal sarcoma. Am. J. vet. Res, 29, 1637–45

    CAS  PubMed  Google Scholar 

  • Warner, N. L., Woodruff, M. A. and Burton, R. C. (1977). Inhibition of the growth of lymphoid tumours in syngeneic athymic nude mice. Int. J. Cancer, 20, 146–55

    Article  CAS  PubMed  Google Scholar 

  • White, R. A. S., Workman, P., Freedman, L., Owen, L. N. and Bleehen, N. M. (1979). The pharmacokinetics of misanidazole in the dog. Eur. J. Cancer in press

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Copyright information

© 1980 The Medical Research Council

About this chapter

Cite this chapter

Owen, L.N. (1980). Transplantation of canine tumours into immunosuppressed dogs and nude mice. In: Sparrow, S. (eds) Immunodeficient Animals for Cancer Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05014-7_10

Download citation

Publish with us

Policies and ethics