Abstract
The problem of allergic reactions to drugs continues to plague patients, physicians and drug manufacturers. Most drug-monitoring studies record about 10 to 15 per cent untoward reactions of hospitalised patients to one or the other drug administered to them; among these 40 to 50 per cent are felt to be of allergic nature (Klein et al., 1972), which leaves us with an overall incidence of about 5 per cent of allergic reactions to drugs in a population of hospitalised patients.
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References
Amkraut, A. A., Rosenberg, L. T. and Raffel, S. (1963). Elicitation of PCA by univalent and divalent haptens. J. Immun., 91, 644
Batchelor, F. R., Dewdney, J. M., Feinberg, J. G. and Weston, R. D. (1967). A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid. Lancet, i, 1175
Bundgaard, H. and de Weck, A. L. (1975). The role of amino-reactive impurities in acetylsalicylic acid allergy. Int. Archs Allergy appl. Immun., 49, 119
Chase, M. W. (1946). Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc. Soc. exp. Biol. Med., 61, 257
Coutinho, A., Möller, G. and Richter, W. (1974). Molecular basis of B cell activation. I. Mitogenicity of native and substituted dextrans. Scand. J. Immun., 3, 321
De Weck, A. L. (1971). Drug reactions. In Immunological diseases, (ed., M. Samter ), Little Brown and Co.,Boston, p. 415
De Weck, A. L. (1975). Molecular mechanisms of T and B lymphocyte triggering. Int. Archs Allergy appl. Immun., 49, 247
De Weck, A. L. (1977). Immune responses to environmental antigens which act on the skin (with special reference to the role of lymphokines in contact dermatitis). Fedn Proc., 36, 1742
De Weck, A. L. (1978). Application du RAST dans l’allergie à la pénicilline. Med. Hyg., 36, 118
De Weck, A. L. and Eisen, H. N. (1960). Some immunochemical properties of penicillenic acid, an antigenic determinant derived from penicillin. J. exp. Med., 112, 1227
De Weck, A. L. and Girard, J. P. (1972). Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten: II. Clinical studies. Int. Archs Allergy appl. Immun., 42, 798
De Weck, A. L. and Schneider, C. H. (1972). Specific inhibitionof allergic reactions to penicillin in man by a monvalent hapten: II. Clinical studies. Int. Archs Allergy, 42, 789
De Weck, A. L., Schneider, C. H. and Gutersohn, J. (1968). The role of penicilloylated pro-tein impurities, penicillin polymers and dimers in penicillin allergy. Int. Archs Allergy appl. Immun., 33, 535
De Weck, A. L., Schneider, C. H., Toffler, O. and Lazary, S. (1973). Inhibition of allergic reactions by monovalent haptens. In Mechanisms of reaginic allergy, (ed., A. Sehon) Dekker, New York, p. 323
De Weck, A. L., Jeunet, F., Schulz, K. H., Louis, P., Girard, J. P., Grilliat, J. P., MoneretVautrin, D., Storck, H., Wiithrich, B., Spengler, H., Juhlin, L., Scheiffarth, F., Warnatz, H., Wortmann, F. and Vigary, S. (1975). Clinical trial of Ro 6–0787: a monovalent specific hapten inhibitor of penicillin allergy. Z. Immunitätsforsch., 150, 138
De Weck„ A. L., Toffler, O., Koleckarova, M. and Spengler, M. (1976). Theoretical basis and experimental studies on the prevention of allergic reactions to penicillins by a monovalent benzylpenicilloyl hapten. Chemotherapy, 4, 345
Dewdney, J. (1977). Immunology of the antibiotics. In The Antigens, IV, (ed., M. Sela ), Academic Press, New York, p. 74
Farah, F. S., Kern, M. and Eisen, H. N. (1960). Specific inhibition of wheal-and-erythema responses with univalent haptens and univalent antibody fragments. J. exp. Med., 112, 1211
Felix, R. H. and Comaish, J. S. (1974). The value of patch and other skin tests in drug eruptions. Lancet, i, 1017
Frick, O. L., Nye, W. and Raffel, S. (1968). Anaphylactic reactions to univalent haptens. Immunology, 14, 563
Green, I., Paul, W. E. and Benacerraf, B. (1966). The behavior of hapten—poly-L-lysine conjugates as complete antigens, in genetic responders and as haptens in nonresponder guinea pigs. J. exp. Med., 123, 859
Howard, J. G. and Mitchison, N. A. (1975). Immunological tolerance. Progr. Allergy, 18, 43
Katz, D. H., Hamaoka, T. and Benacerraf, B. (1972). Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells. J. exp. Med., 136, 1404
Klein, U., Gikalov, I., Keller, M. and Hoigné, R. (1972). Drug monitoring in der medizinischen Abteilung eines Regionalspitals. Schweiz. Med. Wschr., 102, 1083
Kraft, D., Roth, A., Mischer, P., Pichler, H. and Ebner, H. (1977). Specific and total serum IgE measurements in the diagnosis of penicillin allergy. A long-term follow-up study. Clin. Allergy, 7, 21
Kristofferson, A., Ahlstedt, S., Pettersson, E. and Svärd, P. O. (1977). Antigens in penicillin allergy. I. A radioimmunoassay for detection of penicilloylated protein contaminants in penicillin preparations. Im’. Archs Allergy appl. Immun., 55, 13
Lee, W. Y. and Sehon, A. H. (1975). Suppression of reaginic antibody1formation. II. The use of adoptive transfer system for the study of immunological unresponsiveness. J. Immun., 114, 837
Lee, W. Y. and Sehon, A. H. (1976). Suppression of reaginic antibody formation. IV. Suppression of reaginic antibodies to penicillin in the mouse. J. Immun., 117, 927
Levine, B. B. (1966). Immunochemical mechanisms of drug allergy. A. Rev. Med., 17, 23
Magnusson, B. and Kligman, A. M. (1970). Allergic contact dermatitis in the guinea pig, C. C. Thomas, Springfield, Illinois, U.S.A.
Mitchell, G. F., Humphrey,.1 H. and Williamson, A. R. (1972). B cell tolerance induced by polymeric antigens. I. Comparison of the dose and epitope density requirements for inactivation of primed and unprimed B cells in vivo. Eur. J. Immun., 5, 361
Otz, U., Schneider, C. H., de Weck, A. L., Gruden, E. and Gill, T. G. (1978). Induction of immunological tolerance to the penicilloyl antigenic determinant. I. Evaluation of BPO-amino. acid polymers and copolymers in mice. Eur. J. Immun., (in press)
Ovary, Z. and Karush, F. (1960). Studies on the immunologic mechanism of anaphylaxis: I. Antibody—hapten interactions studied by passive cutaneous anaphylaxis in the guinea pig. J. Immun., 84, 409
Paley, R. S. Leskowitz, S. and Borel, Y. (1975). Effect on tolerance induction of the mode of attachment of the hapten to the carrier. J. Immun., 115, 1409
Reismann, R. E., Rose, N. R., Witebsky, E. and Arbesman, C. (1962). Penicillin allergy and desensitization. J. Allergy clin. Immun., 33, 178
Rttegger, R., Spengler, H., de Weck, A. L. and Dubach, U. C. (1973). Immunologische Aspekte der Sensibilisierung auf Phenacetin. Dtsch. Med. Wochenschr., 98, 762
Schneider, C. H., Otz, U. and Gruden, E. (1978). Induction of immunological tolerance to the penicilloyl antigenic determinant. II. Evaluation of stable and unstable penicilloyldextrans. Eur. J. Immun., (in press)
Wide, L. and Juhlin, L. (1971). Detection of penicillin allergy of the immediate-type by radio-immunoassay of reagins (IgE) to penicilloyl conjugates. Clin. Allergy, 1, 171
Zolov, D., Redmond, A. P. and Levine, B. B. (1967). Immunological studies of desensitization in penicillin allergy. J. Allergy clin. Immun., 39, 107
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© 1979 Institute of Biology Endowment Trust Fund
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de Weck, A.L. (1979). Approaches to prevention and treatment of drug allergy. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_13
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DOI: https://doi.org/10.1007/978-1-349-04636-2_13
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