Abstract
Practolol was introudced in 1970 as a cardio-selective ß-adrenoceptor antagonist. In 1973 there were two reports of a systemic lupus erythematosus-like syndrome in a few patients receiving the drug (Assem and Banks, 1973; Raftery and Denman, 1973). During 1974 a hitherto undescribed adverse reaction complex was discerned (Nicholls, 1976). The main features of this rare syndrome are skin rashes (Felix et al. 1974), ocular involvement (Wright, 1975) and a sclerosing peritonitis (Brown et al. 1974) (figure 12.1). This syndrome of adverse reactions is so far unique to practolol and although a variety of minor symptoms and signs have been attributed to other ß-blockers there is no reason to associate them to the very specific features of the practolol-induced oculomucocutaneous syndrome — as is shown very forcibly by the fact that many patients suffering from the practolol adverse reaction have been treated with other (3-blockers without untoward effect (Nicholls, 1976).
Figure 12.1 Practolol-induced oculomucocutaneous syndrome.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amos, H. E. and Brigden, W. D. (1976). Immunological changes and practolol. Lancet, ii, 1298
Amos, H. E., Brigden, W. D. and McKerron, R. A. (1975). Untoward effects associated with practolol: demonstration of antibody binding to epithelial tissue. Br. med. J, I, 598
Amos, H. E., Lake, B. G. and Atkinson, H. A. C. (1977). Allergic drug reactions; an in vitro model using a mixed function oxidase complex to demonstrate antibodies with specificity for a practolol metabolite.
Amos, H. E., Lake, B. G. and Artis, J. (1978). Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome. Br. med. J., I, 402
Assem, E. S. K. and Banks, R. A. (1973). Practolol induced drug eruption. Proc. R. Soc. Med., 66, 179
Behan, P. O., Behan, W. M. H., Zacharias, F. J. and Nicholls, J. T. (1976). Immunological abnormalities in patients who had the oculomucocutaneous syndrome associated with practolol therapy. Lancet, ii, 984
Brown, P., Baddeley, H., Read, A. E., Davies, J. D. and McGarry, J. (1974). Sclerosing peritonitis, an unusual reaction to a beta-adrenergic blocking drug (practolol). Br. med. J., I, 598
Case, D. E., Lindup, W. E., Lowery, C., Orton, T. C., Reeve, P. R. and Whittacker, S. L. (1978). Metabolism studies with practolol. Communication to British Pharmacological Society.
Dahl, M. G. C., Felix, R. H., Ive, F. A. and Wilkins, D. S. (1975). Immunologic aspects of practolol-induced lupus erythematosus. J. invest. Derm., 64, 299
Felix, R. H., Ive, F. A. and Dhal, M. G. C. (1974). Cutaneous and ocular reactions to practolol. Br. med. J., 2, 321
Garner, A. and Rahi, A. H. S. (1976). Practolol and ocular toxicity. Br. J. Ophthal., 60, 684
Jachuck, S. J., Stephenson, J., Bird, T., Jackson, F. S. and Clark, F. (1977). Practolol-induced autoantibodies and their relation to oculocutaneous complications. Postgrad. med. J., 53, 75
Kauppinen, K., Niemi, K. M. and Salo, 0. P. (1976). Cutaneous reactions to practolol. Ann. clin. Res., 8, 232
Mikkelsen, H. I. (1974). Psoriasiforme hudforandringer under praktol (Eraldin) behandling. Ugeskr. Laeg., 136, 2358
Mikkelsen, H. I., Jensen, H. E., Wadskov, S. and Sondergaard J. (1975). Hud-og ojenforandringer ved langtidshehandling med prakotol (Eraldin). Ugeskr. Laeg. 137, 2188
Nicholls, J. T. (1976). Adverse effects of practolol. Ann. clin. Res., 8, 229
Orton, T. C. and Lowery, C. (1977). Irreversible protein binding of [14C]-practolol metabolites to hamster liven microsomes. Br. J. Pharmac., 60, 319 P
Pugh, S., Pelton, B., Raftery, E. B. and Denman, A. M. (1976). Abnormal lymphocyte function is secondary to drug-induced autoimmunity. Ann. rheum. Dis., 35, 344
Raftery, E. B. and Denman, A. M. (1973). Systemic lupus erythematous syndrome induced by practolol. Br. med. J., 2, 452
Rahi, A. H. S., Chapman, C. M., Garner, A. and Wright, P. (1976). Pathology of practolol-induced ocular toxicity. Br. J. Ophthal., 60, 312
Russell, A. S. and Ziff, M. (1968). Natural antibodies to procaine amide. Clin. exp. Immun., 3, 901
Wright, P. (1975). Untoward effects associated with practolol administration: Oculomucocutaneous syndrome. Br. med. J., I, 595
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1979 Institute of Biology Endowment Trust Fund
About this chapter
Cite this chapter
Davies, G.E. (1979). Adverse reactions to practolol. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_12
Download citation
DOI: https://doi.org/10.1007/978-1-349-04636-2_12
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-04638-6
Online ISBN: 978-1-349-04636-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)