Abstract
Specific immunological unresponsiveness, called tolerance, has been described in almost all immunological systems (Katz and Benacerraf, 1974; Howard and Mitchison, 1975; Nossal, 1974). It is of interest that the demonstration of tolerance in delayed hypersensitivity was one of the earliest to be reported (Sulzberger, 1929; Chase, 1946). Bumet’s formulation of the clonal selection theory (Burnet and Fenner, 1949) and Medawar’s (1958) concept of clonal deletion initiated a flood of experimental research that resulted in the general acceptance of a unifying theory of tolerance as an annihilation of the immunocompetent specific cells which was thought to be valid for all immunological systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Asherson, G. L. and Zembala, M. (1974). Suppression of contact sensitivity by T cells in the mouse. I.Demonstration that suppressor cells act on the effector stage of contact sensitivity; and their induction following in vitro exposure to antigen. Proc. R. Soc. B., 197, 320
Asherson, G. L., Mayhew, B., Pereira, M., Thomas, W. R., Wood, P. and Zembala, M. (1977). Distinct suppressor cells which act at different stages of the immune response to contact sensitizing agents in the mouse. Scand. J. Immun., 6, 677
Burnet, F. M. and Fenner, F. (1949). The production of antibodies. McMillan, Melbourne
Chase, M. W. (1946). Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc. Soc. exp. Biol. N.Y., 61, 257
Droege, W. (1973) Five questions on the suppressive effect of thymus-derived cells (Part I and Part II). Current titles in Immunol. Transpl. & Allergy, 1/4, 95 (Part I) 1/5, 131 (Part II)
Frey, J. R., de Weck, A. L. and Geleick, H. (1964). Immunological unresponsiveness in allergic contact dermatitis to dinitrochlorobenzene in guinea pigs. J. invest. Derm.. 42, 41
Hellström, K. E. and Hellström, I. (1974). Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv. Immun., 18, 201
Howard, J. G. and Mitchison, N. A. (1975). Immunological tolerance. Progr. Allergy, 18. 43
Katz, D. H. and Benacerraf, B. (eds) (1974). Immunological tolerance. Mechanisms and potential therapeutic applicâtions. Academic Press, Inc., New York, San Francisco and London
Medawar, P. B. (1958). The Croonian Lecture. The homograft reaction. Proc. R Soc. B., 149, 145
Miller, S. D., Sy, M. S. and Claman, H.N. (1977). The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state. Eur. J. Immun., 7, 165
Moorhead, J. W. (1976). Tolerance and contact sensitivity to DNFB in mice. VI. Inhibition of afferent sensitivity by suppressor T cells in adoptive tolerance. J. Immun., 117, 802
Nossal, G. J. V. (1974). Principles of immunological tolerance and immunocyte receptor blockade. Adv. Cancer Res., 20, 93
Parker, D., Turk, J. L. and Scheper, R. J. (1976). Central and peripheral action of suppressor cells in contact sensitivity in the guinea pig. Immunology, 30, 593
Phanuphak, P., Moorhead, J. W. and Claman, H. N. (1974). Tolerance and contact sensitivity to DNFB in mice. III. Transfer of tolerance with ‘suppressor T cells’. J. Immun., 113. 1230
Polak, L. (1975). The transfer of tolerance to DNCB contact sensitivity in guinea pigs by parabiosis. J. Immun., 114, 988
Polak, L. (1976). Studies on the role of suppressor cells in specific unresponsiveness to DNCB. Immunology, 31, 425
Polak, L. and Geleick, H. (1975). Differing mechanisms of tolerance and desensitization to DNCB in guinea pigs. Eur. J. Immun. 5, 94
Polak, L. and Rinck, C. (1977). Effect of the elimination of suppressor cells on the development of DNCB contact sensitivity in guinea pigs. Immunology, 33, 305
Polak, L. and Turk, J.L. (1974). Reversal of immunological tolerance by cyclophosphamide through the inhibition of suppressor cell activity. Nature, 249, 654
Polak, L., Geleick, H. and Frey, J. R. (1974). The cellular mechanism of tolerance and desensitization in contact hypersensitivity to DNCB in guinea pigs. In Contact Hypersensitivity in Experimental Animals (eds. J. L. Turk and D. Parker). Monogr. Allergy, vol. 8, p. 168, Karger Basel.
Sulzberger, M. D. (1929) Hypersensitiveness to neoarsphenamine in guinea pigs. Archs Derm. Syph. (Chic.), 20, 669
Turk, J. L. (1965). An experimental model for the investigation of the cellular bases of desensitization in contact sensitivity. Int. Archs Allergy, 28, 105
Turk, J. L. and Stone, S. H. (1963). Implications of the cellular changes in lymph nodes during the development and inhibition of delayed type hypersensitivity. In Cell-Bound Antibodies, (eds. Amos and Koprowski ). Wistar Inst. Press., Philadelphia, p. 51
Turk, J. L., Parker, D. and Poulter, L. W. (1972). Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide. Immunology, 23, 493
Voisin, G. Y. (1971). Immunological Facilitation, a broadening of a concept of the enhancement phenomenon. Progr. Allergy, 15, 328
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1979 Institute of Biology Endowment Trust Fund
About this chapter
Cite this chapter
Polak, L. (1979). Tolerance in delayed hypersensitivity. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-349-04636-2_11
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-04638-6
Online ISBN: 978-1-349-04636-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)