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Psychopharmacology of Manic-depressive Illness

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Current Themes in Psychiatry 2

Abstract

The neurochemical and psychopharmacological hypotheses which have thus far been most frequently put forward to explain the pathogenesis of manic-depressive disorders have emphasised the possible role which noradrenaline (NA) and 5–hydroxytryptamine (5–HT) may play (Schildkraut, 1973). It is only recently that another neurotransmitter, dopamine (DA), has been seriously considered as being implicated in this condition.

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References

  • Ahlenius, S., Carlsson, A., Engel, J., Svensson, T. and Persodersten, K. (1973). Antagonism by alpha-methyltyrosine of ethanol-induced stimulation and euphoria in man. Clin. Pharmac. Ther., 14, 586–591

    CAS  Google Scholar 

  • Allen, M. G. (1976). Twin studies of affective illness. Archs gen. Psychiat., 33, 1476–1478

    Article  CAS  Google Scholar 

  • Anden, N. E., Butcher, S. G., Corrodi, H., Fuze, K. and Ungerstedt, U. (1970). Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmac., 11, 303–314

    Article  CAS  Google Scholar 

  • Arbuthnott, G. W. and Murray, L. G. (1975). Dopamine receptor agonists in psychiatric disease. In Advances in Neurology Vol. 9 (Ed. D. B. Caine, T. N. Chase and A. Barbeau ), Raven Press, New York

    Google Scholar 

  • Beigel, A., Murphy, D. L. and Bunney, W. E. (1971). The manic state rating scale. Archs gen. Psychiat., 25, 256–262

    Article  Google Scholar 

  • Brodie, H. K., Murphy, D. L., Goodwin, F. K. and Bunney, W. E. (1971). Catecholamines and mania—the affect of alpha-methylparatyrosine on manic behaviour and catecholamine metabolism. Clin. Pharmac. Ther., 12, 218–224

    CAS  Google Scholar 

  • Bunney, W. E., Gershon, E., Murphy, D. and Goodwin, F. K. (1972). Psychological and pharmacology studies of manic depressive illness. J. Psychiat. Res., 9, 207–226

    Article  CAS  PubMed  Google Scholar 

  • Butcher, L. L. and Engel, J. (1969). Behavioural and biochemical effects of L-dopa after peripheral decarboxylase inhibition. Brain Res., 15, 233–239

    Article  CAS  PubMed  Google Scholar 

  • Cade, J. F. (1949). Lithium salts in the treatment of psychotic excitement. Med. J. Aust., 36, 349–352

    Google Scholar 

  • Carlsson,A. (1970). Amphetamine and brain catecholamines.In Amphetamine and Related Compounds(Ed.E.Costa and S. Garattini ), Raven Press,New York

    Google Scholar 

  • Carlsson, A. and Lindqvist, M. (1963). Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmac. Tox., 20, 140–144

    Article  CAS  Google Scholar 

  • Cookson, J. and Silverstone, T. (1976). 5-Hydroxytryptamine and dopamine pathways in mania; a pilot study of fenfluramine and pimozide. Br. J. clin. Pharmac., 3, 942–943

    Article  CAS  Google Scholar 

  • Corrodi, H., Farnebo. L., Fuxe, K., Hamberger, B. and Ungerstedt, U. (1972). ET-495 and brain catecholamine mechanisms: evidence for stimulation of dopamine receptors. Eur. J. Pharmac., 20, 195–204

    CAS  Google Scholar 

  • Corrodi, H., Fuxe, K., Hokfelt, T., Lidbrink, P. and Ungerstedt, U. (1973). Effects of ergot drugs on central neurones: evidence for stimulation of central dopamine neurones. J. Pharm. Pharmac., 25, 409–410

    Article  CAS  Google Scholar 

  • Dunner, D. L., Fleiss, J. L. and Fieve, R. B. (1976). The course of development of mania in patients with recurrent depression. Am. J. Psychiat., 133, 905–908

    Article  CAS  PubMed  Google Scholar 

  • Feighner, J. P., Robins, E. and Guze, S. B. (1972). Diagnostic criteria for use in psychiatric research. Archs gen. Psychiat., 26, 57–63

    Article  CAS  Google Scholar 

  • Flemenbaum, A. (1974). Does lithium block the effects of amphetamine? A report of three cases. Am. J. Psychiat., 131, 820–821

    CAS  PubMed  Google Scholar 

  • Garattini, S. and Samanin, R. (1976). Anorectic drugs and brain neurotransmitters. In Appetite and Food Intake (Ed. T. Silverstone ), Dahlem Konferenzen, Berlin

    Google Scholar 

  • Geisler, A. and Klysner, R. (1977). Combined effect of lithium and flupenthixol on striatal adenylate cyclase. Lancet, i, 430–431

    Article  Google Scholar 

  • Gerner, R. H., Post, R. M. and Bunney, W. E. (1976). A dopaminergic mechanism in mania. Am. J. Psychiat., 133, 1177–1180

    Article  CAS  PubMed  Google Scholar 

  • Iversen, L. L., Horn, A. and Miller, R. (1975). Actions of dopaminergic agonists on cyclic AMP production in rat brain homogenates. In Advances in Neurology, Vol. 9 (Ed. D. B. Caine. T. N. Chase, A. Barbeau ), Raven Press, New York

    Google Scholar 

  • Janowsky, D. S., El-Yousef, F. and Davis, J. M. (1973). Para-sympathetic suppression of manic symptoms by physostigmine. Archs gen. Psychiat., 28, 542–547

    Article  CAS  Google Scholar 

  • Johnson, A. M., Loew, D. M. and Vigouret, J. M. (1976). Stimulant properties of bromocriptine on central dopamine receptors in comparison to apomorphine (+ )amphetamine and L-dopa. Br. J. Pharmac., 56, 59–68

    Article  CAS  Google Scholar 

  • Johnson, F. N. (1975). Lithium Research and Therapy. Academic Press, London

    Google Scholar 

  • Jonsson, L. E. (1972). Pharmacological blockade of amphetamine effects in amphetamine dependent subjects. Eur. J. Clin. Pharmac., 4, 206–211

    Article  Google Scholar 

  • Jonsson, L. E., Anggard, E. and Gunne, L. M. (1971). Blockade of intravenous amphetamine euphoria in man. Clin. Pharmac. Ther., 12, 889–896

    CAS  Google Scholar 

  • Jonsson, L. E., Gunne, L. M. and Anggard, E. (1969). Effects of alpha-methyltyrosine in amphetamine dependent subjects. Pharmac. Clin., 2, 27–29

    Article  CAS  Google Scholar 

  • Kelly, P. H., Seviour, P. W. and Iversen, S. D. (1975). Amphetamine and apomorphine responses in the rat following 6 OHDA lesions of nucleus accumbens septi and corpus striatum. Brain Res., 94, 507–522

    Article  CAS  PubMed  Google Scholar 

  • Lasagna, L., Von Felsinger, J. M. and Beecher, H. K. (1955). Drug induced mood changes in man. J. Am. Med. Ass., 157, 1006–1015

    Article  CAS  Google Scholar 

  • Lesses, M. F. and Myerson, A. (1938). Benzedrine sulphate as an aid to the treatment of obesity. New Engl. J. Med., 218, 119–124

    Article  CAS  Google Scholar 

  • Mendels, J. and Frazer, A. (1974). Brain biogenic amines and mood. Archs gen. Psychiat., 30, 447–451

    Article  CAS  Google Scholar 

  • Mendels, J. and Frazer, A. (1975). Reduced serotinergic activity in mania. Br. J. Psychiat., 126, 241–248

    Article  CAS  Google Scholar 

  • Murphy, D. L., Brodie, H. K. H., Goodwin, F. K. and Bunney, W. E. (1971). L-dopa: regular induction of hypomania in `bipolar’ manic depressive patients. Nature, 229, 135–136.

    Google Scholar 

  • Murphy, D. L. and Redmond, D. E. (1975). The catecholamines: possible role in affect, mood and emotional behaviour in man and animals. In Catecholamines and Behaviour (Ed. A. Friedhofl ), Plenum Press, New York

    Google Scholar 

  • Papez, J. W. (1937). A proposed mechanism of emotion. Archs Neurol. Psychiat., 38, 725

    Article  Google Scholar 

  • Pare, C. M. B. (1968). The treatment of mania and hypomania. Prescribers J., 8, 113–116

    Google Scholar 

  • Pearce, C. J., Isaacs, A. J. and Gomez, J. (1977). Treatment of Cushing’s disease with cyproheptadine. Lancet, i, 1368–1369

    Article  Google Scholar 

  • Prange, A. J., Wilson I. C., Lynn, C. W., Alltop, L. B. and Stikeleather, R. A. (1974). L-tryptophan in mania. Archs gen. Psychiat., 30, 56–62

    Article  Google Scholar 

  • Randrup, A., Munkvad, I., Fog, R., Gerlach, J., Molander, L., Kjellborg, B. and Scheel-Kruger, J. (1975). Mania, depression and brain dopamine. Curr. Dev. Psychopharmac., 2, 207–247

    Google Scholar 

  • Rubin, R. T., Poland, R. E., O’Connor, D., Govin, P. R. and Tower, B. B. (1976). Selective neuroendocrine effects of low dose haloperidol in normal adult men. Psychopharmacology, 47, 135–140

    Article  CAS  Google Scholar 

  • Sack, R. L. and Goodwin, F. K. (1974). Inhibition of dopamine- ß -hydroxylase in manic patients. Archs gen. Psychiat., 31, 649–654

    Article  CAS  Google Scholar 

  • Schildkraut, J. J. (1973). Neuropharmacology of the affective disorders. A. Rev. Pharmac., 15, 427–454

    Article  Google Scholar 

  • Schou, M., Juel-Nielson, N., Stromgren, E. and Voldby, H. (1954). The treatment of manic psychosis by the administration of lithium salts. J. Neurol. Neurosurg. Psychiat., 17, 250–260

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shapiro, R. W., Bock, E., Rafaelson, O., Ryder, L. P. and Svejgaard, A. (1976). Histocompatability antigens and manic depressive disorders. Archs gen. Psychiat., 33, 823–825

    Article  CAS  Google Scholar 

  • Shopsin, B., Gershon, S. and Selzer, G. (1976). Neuropsychopharmacology of mania. In Drug Treatment of Mental Disorders (Ed. L. Simpson ), Raven Press, New York

    Google Scholar 

  • Spector, S., Sjoerdsma, A. and Undenfriend, S. (1965). Blockade of endogenous norepinephorine synthesis by alpha-methyl-tyrosine, an inhibitor of tyrosine hydroxylase. J. Pharmac. Exp. Ther., 147, 86–95

    CAS  Google Scholar 

  • Turner, P. (1971). Drugs and the special senses. Seminars in Drug Treatment, 4, 335–352

    Google Scholar 

  • Van Kammen, D. P. and Murphy, D. L. (1975). Attentuation of the euphoriant and activating effects of d- and 1-amphetamine by lithium carbonate treatment. Psychopharmacologia, 44, 215–224

    Article  PubMed  Google Scholar 

  • Van Praag, H. M. and Korf, J. (1976). Importance of dopamine metabolism for clinical effects and side effects of neuroleptics. Am. J. Psychiat., 133, 1171–1177

    Article  PubMed  Google Scholar 

  • Weiss, B. and Laties, V. G. (1962). Enhancement of human performance by caffeine and the amphetamines. Pharmac. Rev., 14, 1–36

    CAS  Google Scholar 

  • Winokur, G., Clayton, P. J. and Reich, T. (1969). Manic-depressive Illness. C. V. Mosby, St. Louis

    Google Scholar 

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Authors
  1. Trevor Silverstone
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© 1979 Raghu N. Gaind and Barbara L. Hudson

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Silverstone, T. (1979). Psychopharmacology of Manic-depressive Illness. In: Current Themes in Psychiatry 2. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04494-8_21

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  • DOI: https://doi.org/10.1007/978-1-349-04494-8_21

  • Publisher Name: Palgrave Macmillan, London

  • Print ISBN: 978-1-349-04496-2

  • Online ISBN: 978-1-349-04494-8

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