Abstract
A major factor responsible for the improved treatment results in children with acute lymphoblastic leukaemia has been the institution of central nervous system (CNS) prophylaxis which has markedly reduced the incidence of meningeal disease (Mauer and Simone, 1976). However, meningeal leukaemia still occurs and the treatment of this complication poses a major therapeutic challenge.
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© 1979 D. Gangji, L. Cohen, W. A. Bleyer, R. Vigerski, D. Glaubiger and D. G. Poplack
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Gangji, D., Cohen, L., Bleyer, W.A., Vigerski, R., Glaubiger, D., Poplack, D.G. (1979). Methotrexate CNS Pharmacokinetics in Combination Chemotherapy. In: Whitehouse, J.M.A., Kay, H.E.M. (eds) CNS Complications of Malignant Disease. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04285-2_38
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DOI: https://doi.org/10.1007/978-1-349-04285-2_38
Publisher Name: Palgrave Macmillan, London
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