Adipose tissue in genetically obese rodents
Genetically determined obesity in rodents is associated with fat cell hypertrophy (always) and hyperplasia (often).
Fat cell hypertrophy can be detected in obese rodents in the early postnatal period.
Although studies of adipose tissue metabolism from obese and lean animals have produced contradictory results, adipose tissue of obese rodents is generally agreed to be geared towards fat storage and away from fat breakdown. This is particularly true for young animals in the dynamic phase of obesity.
Fat transplantation experiments using a wide range of genetically obese rodents indicate that adipose tissue hypertrophy is readily reversible. Host environment is more important than intrinsic factors in determining the size of fat cells in grafts.
Since fat cell size increases so early in obese rodents, yet, from transplantation experiments, is likely to be a secondary defect, the primary defect in genetically obese rodents must therefore be present in the immediate post-natal period, if not prenatally.
KeywordsAdipose Tissue Diabetic Mouse Obese Mouse Lean Mouse Epididymal Adipose Tissue
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- Ashwell, M. (1978). The ‘fat cell pool’ concept. Int. J. Obesity, 2, 69–72Google Scholar
- Ashwell, M., Meade, C. J., Medawar, P. B. and Sowter, C. (1977b). Adipose tissue: contributions of nature and nurture to the obesity of an obese mutant mouse (ob/ob). Proc. Nutr. Soc., 36, 16AGoogle Scholar
- Ashwell, M. A., Priest, P., Bondoux, M., Sowter C. and McPherson, C. K. (1976). Human fat cell sizing-a quick simple method. J. Lipid Res., 17, 190–192Google Scholar
- Ashwell, M. and Trayhurn, P. (1979). In preparationGoogle Scholar
- Bach-Mortensen, N., Romert, P. and Ballegaard, S. (1976). Transplantation of human adipose tissue to nude mice. Acta Pathol. Microbiol. Scand., Section C, 84, 283–289Google Scholar
- Bergen, W. G., Kaplan, M. L., Merkel, R. A. and Leveille, G. A. (1975). Growth of adipose and lean tissue mass in hind limbs of genetically obese mice during preobese and obese phases of development. Am. J. Clin. Nutr., 28, 157–161Google Scholar
- Billingham, R. E. and Medawar, P. B. M. (1951). The technique of free skin grafting in mammals. J. Exp. Biol., 28, 385–402Google Scholar
- Bjorntorp, P. (1978). The fat cell: A clinician’s view. In Recent Advances in Obesity Research, Vol. II (ed. G. A. Bray), Newman, London, pp. 153–168Google Scholar
- Boulange, A., Planch, E. and de Gasquet, P. (1977). Excess fat storage and normal energy intake in the newborn Zucker rat (fa/fa). Abstract presented at the 2nd International Congess of Obesity, Washington, DCGoogle Scholar
- Bray, G. A. (1977). The Zucker-fatty rat: a review. Fed Proc., 36, 148–153Google Scholar
- Frantz, M. K., Kirschbaum, A. and Casas, C. (1947). Endocrine interrelationship and spontaneous tumours of the adrenal cortex in NH mice. Proc. Soc. Exp. Biol. Med., 66, 645–646Google Scholar
- Fried, G. H. and Antopol, W. (1960). Alpha-glycerophosphate oxidation in the tissues of obese hyperglycaemic mice and nonobese controls. Fed. Proc., 19, 327 (abstract)Google Scholar
- Fried, G. H. and Antopol, W. (1963). Oxygen consumption in litters of obese hyperglycaemic mice. Fed. Proc., 22, 668 (abstract)Google Scholar
- Hausberger, F. X. (1957). Composition of adipose tissue in several forms of obesity. Anat. Rec., 127, 305 (abstract)Google Scholar
- Hollifield, G., Parson, W. and Ayers, C. R. (1960). In vitro synthesis of lipids from 14C-acetate by adipose tissue from four types of obese mice. Am. J. Physiol., 198, 37–38Google Scholar
- Johnson, P. R. and Hirsch, J. (1972). Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res., 13, 2–11Google Scholar
- Johnson, P. R., Zucker, L. M., Cruce, J. A. F. and Hirsch, J. (1971). Cellularity of adipose depots in the genetically obese Zucker rat. J. Lipid Res., 12, 706–714Google Scholar
- Lemonnier, D. and Alexiu, A. (1974). Nutritional, genetic and hormonal aspects of adipose tissue cellularity. In The Regulation of Adipose Tissue Mass (ed. J. Vague and J. Boyer ), Excerpta Medica, Amsterdam, pp. 158–173Google Scholar
- Martin, R. J. (1974). In vivo lipogenesis and enzyme levels in adipose and liver tissues from pair-fed genetically obese and lean rats. Life Sci., 14, 1447–1453Google Scholar
- Martin, R. J., Welton, R F. and Baumgardt, B. R. (1973). Adipose and liver tissue enzyme profiles in obese hyperglycemic mice. Proc. Soc. Exp. Biol. Med., 142, 241–245Google Scholar
- Meade, C. J., Ashwell, M. and Medawar, P. B. (1977a). Adipose tissue: contributions of nature and nurture to obesity in obese rodents. Abstract presented at 2nd International Congress of Obesity, Washington, DCGoogle Scholar
- Meade, C. J., Ashwell, M., Medawar, P. B. and Sowter, C. (1977b). Can genetically trans- mitted obesity be ascribed to an adipose tissue defect? Proc. Nutr. Soc., 36, 114AGoogle Scholar
- Rakow, L. (1974). Cellularity of the different cell compartments in white adipose tissue of mice in chronic starvation, refeeding and in two types of obesity. In The Regulation of the Adipose Tissue Mass (ed. J. Vague and J. Boyer ), Excerpta Medica, Amsterdam, pp. 140–144Google Scholar
- Renold, A. E. Christophe, J. and Jeanrenaud, B. (1960). The obese hyperglycemic syndrome in mice. Metabolism of isolated adipose tissue in vitro. Am. J. Clin. Nutr., 8, 719–726Google Scholar
- Robertson, R. P. Batchelor, B. R., Johnson, P. R. and Stern, J. S. (1974). Adipocyte cellularity in the desert sand rat (Psammomys obesus). Proc. Soc. Exp. Biol. Med. 147 134136Google Scholar
- Taljedal, I.-B. and Hellman, B. (1963). Morphological characteristics of the epididymal adipose tissue in different types of hereditary obese mice. Pathol. Microbiol., 26, 149–157Google Scholar
- van der Croon, P. H. N., Van Vroonhoven and Douglas, L. T. (1977). Lowered oxygen consumption and heart rate as early symptoms of the obese, hyperglycemic syndrome in mice (ob/ob). Int. J. Obesity, 1, 325–330Google Scholar
- Wahle, K. W. J. (1974). Fatty acid composition and desaturase activity of tissues of the congenitally obese Zucker rat. Comp. Biochem. Physioi, 48B, 565–574Google Scholar
- Zomzely, G. and Mayer, J. (1959). Fat metabolism in experimental obesities. IX. Lipogenesis and cholesterogenesis in yellow obese mice. Am. J. Physiol., 196, 611–613Google Scholar