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Abnormal function of the endocrine pancreas in genetic and experimentally induced obesity in rodents

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Animal Models of Obesity

Summary

Hyperinsulinaemia is a consistent feature of obesity; studies on the hyperactivity of the β-cell function of the endocrine pancreas in experimental and genetic obesity in rodents are described. Evidence that the hypersecretion of insulin may be one of the primary defects in many forms of obesity is discussed. Adrenal cortical hyperplasia and increased circulating glucocorticosteroids, as well as high pituitary ACTH levels, are among the multiple endocrine abnormalities described in the ob/ob mice.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Imperial College of Science and Technology, London, UK

    Anne Beloff-Chain

Authors
  1. Anne Beloff-Chain
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Editor information

Editors and Affiliations

  1. Medical Research Council Laboratory Animals Centre, Carshalton, Surrey, UK

    Michael F. W. Festing B.Sc., M.Sc., Ph.D., M.I.S., M.I.Biol.

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© 1979 The Medical Research Council

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Beloff-Chain, A. (1979). Abnormal function of the endocrine pancreas in genetic and experimentally induced obesity in rodents. In: Festing, M.F.W. (eds) Animal Models of Obesity. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04201-2_6

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