β-Endorphin therapy in psychiatric patients

  • Nathan S. Kline
  • Heinz E. Lehmann

Abstract

Several years ago our interest was aroused when the effects of several polypeptides were described. In view of the fact that opiates have a long history in the folk as well as modern medical treatment of depression, the availability of opiate peptides was intriguing. Preliminary agreement was therefore reached with C. H. Li two years ago that when synthesized and purified in adequate quantities, we would have the opportunity of evaluating the therapeutic action of the opiate peptides. In June of this year we administered small doses of β-endorphin to the first five patients. Patients were selected on the following criteria
  1. (1)

    Severity of illness;

     
  2. (2)

    Failure of extensive previous treatment.

     

Keywords

Placebo Depression Schizophrenia Morphine Valium 

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References

  1. Aubert, M. L., Grumbach, M. M. and Kaplan, S. L. (1974). Acta Endocr., 77, 460–76PubMedGoogle Scholar
  2. Bloom, F., Segal, D., Ling, N. and Guillemin, R. (1976). Science, 194, 630–2PubMedCrossRefGoogle Scholar
  3. Li, C. H., Jagannadha Rao, A., Doneen, B. A. and Yamashiro D. (1977). Biochem. biophys.Res. Commun., 71, 576–80CrossRefGoogle Scholar

Copyright information

© The contributors 1979

Authors and Affiliations

  • Nathan S. Kline
    • 1
  • Heinz E. Lehmann
    • 2
  1. 1.Rockland Research InstituteOrangeburg, New YorkUSA
  2. 2.McGill UniversityMontrealCanada

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