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Effects of endorphins and their analogues on prolactin and growth hormone secretion

  • F. Labrie
  • A. Dupont
  • L. Cusan
  • J. C. Lissitzky
  • J. Lepine
  • V. Raymond
  • D. H. Coy

Abstract

Following reports of the presence of endogenous opiate activity in brain (Hughes, 1975; Pasternak et al., 1975; Terenius et al., 1975), the pentapeptide Tyr-GlyGly-Phe-Met (met-enkephalin) has been isolated from porcine (Hughes et al., 1975) and calf (Simantov et al., 1976) brain. The sequence of this peptide is the same as the N-terminus of the C-fragment (ß-LPH61-91), also called ß-lipotropin, first isolated from sheep pituitaries (Li et al., 1965). Both met-enkephalin and ß-endorphin have potent morphine-like activity (Chang et al., 1976; Hughes et al., 1975; Li et al., 1976a) and bind to the opiate receptor (Chang et al., 1976; Li et al., 1976b; Morin et al., 1976).

Keywords

Growth Hormone Response Growth Hormone Release Mental Health Research Plasma Growth Hormone Growth Hormone Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The contributors 1979

Authors and Affiliations

  • F. Labrie
    • 1
  • A. Dupont
    • 1
  • L. Cusan
    • 1
  • J. C. Lissitzky
    • 1
  • J. Lepine
    • 1
  • V. Raymond
    • 1
  • D. H. Coy
    • 1
  1. 1.Laboratory of Molecular EndocrinologyLe Centre Hospitalier de l’Université LavalQuebec G 1V 4G2Canada

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