Effects of endorphins and their analogues on prolactin and growth hormone secretion
Following reports of the presence of endogenous opiate activity in brain (Hughes, 1975; Pasternak et al., 1975; Terenius et al., 1975), the pentapeptide Tyr-GlyGly-Phe-Met (met-enkephalin) has been isolated from porcine (Hughes et al., 1975) and calf (Simantov et al., 1976) brain. The sequence of this peptide is the same as the N-terminus of the C-fragment (ß-LPH61-91), also called ß-lipotropin, first isolated from sheep pituitaries (Li et al., 1965). Both met-enkephalin and ß-endorphin have potent morphine-like activity (Chang et al., 1976; Hughes et al., 1975; Li et al., 1976a) and bind to the opiate receptor (Chang et al., 1976; Li et al., 1976b; Morin et al., 1976).
KeywordsGrowth Hormone Response Growth Hormone Release Mental Health Research Plasma Growth Hormone Growth Hormone Concentration
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- Bloom, F., Segal, D., Ling, N. and Guillemin, R. (1976). Nature, 194, 630 - 6Google Scholar
- Pert, A. (1977). In Opiates and Opioid Peptides, (eds H. Kosterlitz, S. Archer, E. J. Simon and A. Goldstein), Elsevier Publishing Co., Amsterdam, pp. 87 - 94Google Scholar
- Schally, A. V., Dupont, A., Arimura, A., Takahara, J., Redding, T. W., Clemens, J. and Shaar, C. (1976). Acta endocrin., 82, 1 - 14Google Scholar