Substance P: a historical account
Substance P (SP) was first detected (von Euler and Gaddum, 1931) during a search for acetylcholine in alcoholic extracts of brain and intestine of the rabbit. These extracts contracted the isolated intestine and lowered the rabbit’s blood pressure, but contrary to expectation these actions were resistant to atropine. It soon became clear that the extracts owed their biological activity not to acetylcholine, histamine or derivatives of adenylic acid, but to material of polypeptide nature (von Euler, 1936). The name ‘Substance P’ appeared first in a paper by Gaddum and Schild (1934).
KeywordsRecombination Chloroform Morphine Serotonin Fractionation
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