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Substance P: a historical account

  • F. Lembeck
Part of the Biological Council book series

Abstract

Substance P (SP) was first detected (von Euler and Gaddum, 1931) during a search for acetylcholine in alcoholic extracts of brain and intestine of the rabbit. These extracts contracted the isolated intestine and lowered the rabbit’s blood pressure, but contrary to expectation these actions were resistant to atropine. It soon became clear that the extracts owed their biological activity not to acetylcholine, histamine or derivatives of adenylic acid, but to material of polypeptide nature (von Euler, 1936). The name ‘Substance P’ appeared first in a paper by Gaddum and Schild (1934).

Keywords

Aqueous Phase Aqueous Extract Total Lipid Extract Chloroform Phase Peripheral Nerve Ending 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • F. Lembeck
    • 1
  1. 1.Institut für experimentelle und klinische Pharmakologie der Universität GrazUniversitätsplatz 4GrazAustria

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