Abstract
Hughes and his colleagues were the first to describe the structure of the enkephalins, two naturally occurring pentapeptides which have high affmity for the opiate receptor (Hughes et al., 1975). It has been pointed out that the structure of these peptides is related to that of β-lipotropin, a 91 amino acid hormone found in the pituitary gland. Moreover further peptides have now been described which have opiate activity and represent longer sequences of the C-terminal portion of β-lipotropin. These longer peptides are generally known as endorphins. The largest of these is β-endorphin which represents residues 61–91 of β-lipotropin. [Met5]-enkephalin actually represents residues 61–65 of β-lipotropin (Simantov and Snyder, 1976a; Lazarus et al., 1976; Cox et al., 1976; Bradbury et al.,1976a).
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References
Beddell, C. R., Clark, R. B., Hardy, G. W., Lowe, L. A., Ubatuba, F. B., Vane, J. R., Wilkinson, S., Miller, R. J., Chang, K-J. and Cuatrecasas, P. (1977). Proc. R. Soc. B, 198, 249–65
Belluzzi, J. D., Grant, N., Garsky, V., Sarantakis, D., Wise, C. D. and Stein, L. (1976). Nature, 260, 625–26
Bloom, F., Battenberg. E., Rossier, J., Ling, N., Leppaluoto, J., Vargo, T. M. and Guillemin, R. (1977). Life Sci., 20, 43–48
Bradbury, A. F., Feldberg, W. F., Smyth, D. G. and Snell, C. K. (1976a) In Opiates and Endogenous Opiate Peptides (ed. H. Kosterlitz ), North-Holland, Amsterdam, pp. 9–18
Bradbury, A. F., Smyth, D. G., Snell, C. K., Birdsall, N. J. M., and Hulme, E. C. (1976b). Nature, 260, 794–95
Bradbury, A. F., Smyth, D. G. and Snell, C. R. (1976c). Nature, 260, 165–66
Cox, B. M., Goldstein, A. and Li, C. H. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 1821–23
Elde, R., Hökfelt, T., Johansson O. and Terenius L. (1976). Neurosci. Lett., 1, 349–51
Feinberg, A., Creese, I. and Snyder S. H. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 4215–19
Hughes, J. (1975). Brain Res., 88, 295–308
Hughes, J., Smith, T. W., Kosterlitz, H. W., Forthergill, L. A., Morgan, B. A. and Morris, H. R. (1975). Nature, 258, 577–79
Hutchinson, M., Kostelitz, H. W., Frances, C. M., Terenius, L. and Waterfield, A. M. (1975). Br. J. Pharmac., 55, 541–42
Jones, C. R., Gibbons, W. A., and Garsky, V. (1976). Nature, 262, 779–82
Lazarus, L. H., Ling, N. and Guillemin, R. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 2156–59
Lewis, P. N., Momany, F. A. and Scheraga, H. A. (1973). Biochim. biophys. Acta, 303, 211–29
Lord, J. A. H., Waterfield, A. M., Hughes, J. and Kosterlitz, H. (1976). In Opiates and Endogenous Opiate Peptides (ed. H. Kosterlitz) North-Holland, Amsterdam, pp. 275–80
Matthews, B. W. (1972). Macromolecules, 5, 818–19
Miller, R. J., Chang, K-J., Cuatrecasas, P. and Wilkinson, S. (1977a). Biochem. biophys. Res. Commun., 74, 1311–18
Miller, R. J., Chang, K-J., Leighton, G. and Cuatrecasas, P. (1977b). Life Sci., (in press)
Miller, R. J., Chang, K-J., Cooper, B. and Cuatrecasas, P. (1978). J. biol. Chem., (in press)
Nemethy, G. and Printz, M. P. (1972). Macromolecules, 5, 755–58
Pert, C. B. and Snyder, S. H. (1974). Molec. Pharmac., 10, 868–78
Pert, C. B., Bowie, D. L., Fong, B. T. S. and Chang, J-K. (1976). In Opiates and Endogenous Opiate Peptides (ed. H. Kosterlitz ), North-Holland, Amsterdam, pp. 79–86
Pert, C. B., Pert, A. and Tallman, J. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 2226–30
Ramakrishnan, C. and Ramachandran, G. N. (1965). Biophys. J., 5, 909–33
Roques, B. P., Garbay-Jallreguiberry, C., Oberlin, R., Anteunis, M. and Lala, A. K. (1976). Nature, 267, 778–9
Simantov, R. and Snyder, S. H. (1976a) Proc. natn. Acad. Sci. U.S.A., 73, 2515–19
Simantov, R. and Snyder, S. H. (1976b). In Opiates and Endogenous Opiate Peptides (ed. H. Kosterlitz ), North-Holland, Amsterdam, pp. 41–49
Simantov, R., Kuhar, M. J. and Snyder, S. H. (1977). Proc. natn. Acad. Sci. U.S.A., (in press).
Snyder, S. H. and Simantov, R. (1977). J. Neurochem., 28, 1320
Weissman, B. A., Gershon, H. and Pert, C. B. (1976). FEBS Lett., 70, 245–48
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Miller, R.J. et al. (1978). Distribution and pharmacology of the enkephalins and related opiate peptides. In: Hughes, J. (eds) Centrally Acting Peptides. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03668-4_13
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DOI: https://doi.org/10.1007/978-1-349-03668-4_13
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