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Cobalt-Induced Epilepsy in the Rat: Some Studies on the Mirror Focus

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Structure and Function of Cerebral Commissures
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Abstract

The corpus callosum is known to be of primary importance in the propagation of focal epileptic activity from one hemisphere to a contralateral homotopic point. Various workers (Morrell, 1960; Mutani et al., 1973; Woodruff, 1975) have established that section of the corpus callosum prevents the spread of focal seizures produced by agents like penicillin or ethyl chloride. However, Isaacson et al. (1971) and Nie et al. (1974) have described, in addition, the possibility of descendant propagation into subcortical structures and subsequent spread into cortical areas as an alternative route.

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References

  • Ashcroft, G. W., Dow, R. C., Harris, P., Hill, A. G., Ingleby, J., McQueen, J. K. and Townsend, H. R. A. (1972). Effects of surgical lesions on cobalt-induced epileptic foci in the rat. Proc. Fifth European Symposium on Epilepsy (M. J. Parsonage, ed.), pp. 109–15

    Google Scholar 

  • Bures, J., Buresova, O. and Fifkova, E. (1964). Interhemispheric transfer of a passive avoidance reaction. J. comp. physiol. Psychol., 57, 326–30

    Article  PubMed  CAS  Google Scholar 

  • Clayton, P. R. and Emson, P. C. (1976). Spread of cobalt from a cortical epileptic lesion induced by a cobalt-gelatine implant into the frontal cortex of the rat. Experientia, 32, 1303–1305

    Article  PubMed  CAS  Google Scholar 

  • Dow, R. C., McQueen, J. K. and Townsend, H. R. A. (1972). The production and detection of epileptogenic lesions in rat cerebral cortex. Epilepsia, 13, 459–65

    Article  PubMed  CAS  Google Scholar 

  • Hill, A. G. and Townsend, H. R. A. (1973). The automatic estimation of epileptic spike activity. Int. J. Bio-Med. Computing, 4, 149–56

    Article  CAS  Google Scholar 

  • Isaacson, R. L., Schwartz, H., Persoff, N. and Pinson, L. (1971). The role of the corpus callosum in the establishment of areas of secondary epileptiform activity. Epilepsia, 12, 133–46

    Article  PubMed  CAS  Google Scholar 

  • Kopeloff, N., Kennard, M. A., Pacella, B. L., Kopeloff, L. M. and Chusid, J. G. (1950). Section of corpus callosum in experimental epilepsy in the monkey. Archs Neurol. Psychiat., 63, 719–27

    Article  CAS  Google Scholar 

  • Morrell, F. (1960). Secondary epileptogenic lesions. Epilepsia, 1, 538–60

    Article  PubMed  CAS  Google Scholar 

  • Mutani, R., Bergamini, L., Fariello, R. and Quattrocolo, G. (1973). An experimental investigation of the mechanisms of interaction of asymmetrical acute epileptic foci. Epilepsia, 13, 597–608

    Article  Google Scholar 

  • Nie, V., MacCabe, J. J., Ettlinger, G. and Driver, M. V. (1974). The development of secondary epileptic discharges in the rhesus monkey after commissure section. Electroenceph. clin. NeurophysioL, 37, 473–81

    Article  PubMed  CAS  Google Scholar 

  • Pitman, R. M., Tweedle, C. D. and Cohen, M. J. (1972). Branching of central neu-rons: intracellular cobalt injection for light and electron microscopy. Science 176, 412–14

    Article  PubMed  CAS  Google Scholar 

  • Racine, R., Okujava, V. and Chipashvili (1972). Modification of seizure activity by electrical stimulation. III Mechanisms. Electroenceph. clin. NeurophysioL, 32, 295–99

    Article  PubMed  CAS  Google Scholar 

  • Wada, J. A. and Sato, M. (1975). The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split brain cats. Epilepsia, 16, 417–30

    Article  PubMed  CAS  Google Scholar 

  • Woodruff, M. L. (1975). Midbrain and callosal influences on the spread of focal cortical epileptic activity. Brain Res., 85, 53–8

    Article  PubMed  CAS  Google Scholar 

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© 1979 I. Steele Russell, M. W. van Hof and G. Berlucchi

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McQueen, J.K., Dow, R.C. (1979). Cobalt-Induced Epilepsy in the Rat: Some Studies on the Mirror Focus. In: Russell, I.S., van Hof, M.W., Berlucchi, G. (eds) Structure and Function of Cerebral Commissures. Palgrave, London. https://doi.org/10.1007/978-1-349-03645-5_12

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