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Hypothalamic peptide hormones and their analogues

  • A. V. Schally
  • D. H. Coy
  • A. Arimura
  • T. W. Redding
  • A. J. Kastin
  • C. Meyers
  • J. Seprodi
  • R. Chang
  • W.-Y. Huang
  • K. Chihara
  • E. Pedroza
  • J. Vilchez
  • R. Millar

Abstract

Although various anatomical and physiological data discussed elsewhere in this book supported the concept of hypothalamic control of the pituitary gland (Green and Harris, 1947), direct evidence for the existence of hypothalamic hormones involved in the release of pituitary hormones was lacking until Saffran and Schally (1955) demonstrated the presence of a corticotrophin releasing factor (CRF) in hypothalamic and neurohypophyseal extracts. This opened the way for subsequent discoveries of other hypothalamic regulatory substances. The existence of at least nine hypothalamic regulatory hormones is now established with some certainty (see table 6.1), and four of these substances, thyrotrophin releasing hormone (TRH), luteinising hormone-releasing hormone/follicle stimulating hormone-releasing hormone (LH-RH/FSH-RH), somatostatin, and MSH-release inhibiting factor (MIF), have been isolated in pure state, structurally identified, and synthesised. These substances were also previously called “factors”.

Keywords

Luteinising Hormone Follicle Stimulate Hormone Corticotrophin Release Factor Thyrotrophin Release Hormone Luteinizing Hormone Release Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© B. Cox, I. D. Morris and A. H. Weston 1978

Authors and Affiliations

  • A. V. Schally
    • 1
    • 2
  • D. H. Coy
    • 1
    • 2
  • A. Arimura
    • 1
    • 2
  • T. W. Redding
    • 1
    • 2
  • A. J. Kastin
    • 1
    • 2
  • C. Meyers
    • 1
    • 2
  • J. Seprodi
    • 1
    • 2
  • R. Chang
    • 1
    • 2
  • W.-Y. Huang
    • 1
    • 2
  • K. Chihara
    • 1
    • 2
  • E. Pedroza
    • 1
    • 2
  • J. Vilchez
    • 1
    • 2
  • R. Millar
    • 3
  1. 1.Department of MedicineTulane University School of MedicineNew OrleansUSA
  2. 2.Endocrine and Polypeptide LaboratoryVeterans’ Administration HospitalNew OrleansUSA
  3. 3.Department of Chemical Pathology, Medical SchoolObservatoryCape TownSouth Africa

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