Summary
Haemoperfusion over a packed bed alumina column is suggested for the removal of excess phosphate ions from the blood of uraemic patients. The alumina particles are coated with blood compatible phosphate-permeable polymers. Poly-HEMA and collodion-based coatings have been tested in preliminary in vitro simulated haemoperfusion experiments with fresh human blood. Collodion based coatings exhibit good blood compatibility. Additional work is required to define the limitations and refine the proposed system.
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References
Alfrey, A. C., Kaehny,W. D., Nunnelley, L. L. and Smythe, W. R. (1975). The dialysis encephalopathy syndrome (DE). Possible aluminium intoxication. Kidney International, 8, 422.
Andrade, J. D. and Kolff, K. J. (1973). Development of more efficient, less costly artificial kidneys: Adsorbent haemoperfusion. Annual Report to NIH, August 1973.
Andrade, J. D., Coleman, D. L., Kim, S. W. and Lentz, D. J. (1975). The coating of activated carbons for optimal blood compatibility, in R. Williams, and I. M. Murray-Lyon, (Eds.), Artificial Liver Support, Pitman Medical, London.
Arora, K. K., Lacy, J. P., Schacht, R. A., Martin, D. G. and Gutch, C. G. (1975). Calcific cardiomyopathy in advanced renal failure. Arch. Intern. Med., 135, 603.
Berlyne, G. M., (1976). Dialysis dementia: aluminium again. Lancet, 2, 349.
Brookings, C. H. and Ramsey, J. D. (1975). Salicylate removal by charcoal haemoperfusion in experimental intoxication in dogs: Assessment of efficacy and safety. Arch. Toxicol., 34 (3), 243.
Chang, T. M. S., Gonda, A., Dirks, J. and Malave, N. (1971). Clinical evaluation of chronic intermittent or short-term haemoperfusion in patients with chronic renal failure using semipermeable microcapsules (artificial cells) formed from membrane-coated activated charcoal. Trans. Amer. Soc. Artif. Int. Organs, 17, 246.
Chang, T. M. S., (1972). Artificial Cells, Thomas, Springfield, Illinois.
Chesney, R. W. and Haughton, P. B. (1974). Tetany following phosphate anaemias in chronic renal disease. Amer. J. Dis. Child., 127, 584.
Denti, E., Luboz, M. P., Tessore, V. A., Castino, F., Gaglia, P. F. (1975). Adsorbents in haemoperfusion. Kidney International, 7, S401.
Flendrig, J. A., Kruis, H. and Das, H. A. (1976). Aluminium intoxication: the cause of dialysis dementia. Proc. Eur. Dial. Transpl. Assoc., 13, 355.
Gazzard, B. G., Langley, P. G., Weston, M. J., Dunlop, E. H. and Williams, R. (1974). Polymer coating of activated charcoal and its effects on biocompatibility and paracetamol binding. Clin. Sci. Mol. Med., 47, 97–104.
Hoffer, E., Rousseau, I., Sideman, S., Better, O. and Raziel, A. (1975). Selective removal of waste metabolites from blood serum. Abstracts, 24th International Symposium on Macromolecules, Jerusalem, July 1975.
Lindsay, R. M., Prentice, C. R. M., Davidson, J. F., Burton, J. A. and McNicol, G. P. (1972). Haemostatic changes during dialysis associated with thrombus formation on dialysis membranes. Brit. Med. J., 11, 454–458.
Moise, O., Sideman, S., Hoffer, E., Rousseau, I. and Better, O. S. (1976). Membrane permeability for inorganic phosphate ions. Technion Research and Development Foundation Research Report August 1976.
Neufeld, R. D. and Thodos, G. (1969). Removal of orthophosphates from aqueous solutions with activated alumina. Environ, Sci. and Technol., 3, 661.
Nishizawa, E. E., Wynalda, D. J. and Lednicer, D. (1973). Nonthrombogenic surface with Evan’s blue, in P. Didisheim et al. (Eds.), Platelets, Thrombosis and Inhibitors, Proc. Honolulu-US-Japan Meeting, Schattauer Verlag, p. 135.
Sideman, S. and Better, O. (1973). Selective removal of waste metabolites from blood serum. Research proposal 070 147/P, Technion Research and Development Foundation, December 1973.
Townsend, C. M., Remmers, A. R., Srales, H. E. and Fish, J. C. (1973). Intestinal obstruction from medication in patients with renal failure. New Engl. J. Med., 288, 1058.
Vale, J. A., Rees, A. J., Widdop, B. and Goulding, R. (1975). Use of charcoal haemoperfusion in the management of severely poisoned patients. Brit. Med. J., 1, 5.
Ward, M. K., Pierides, A. M., Fawcett, P., Shaw, D. A., Perry, R. H., Tomlinson, B. E. and Kerr, D. N. S. (1976). Dialysis encephalopathy syndrome. Proc. Eur. Dial. Transpl. Assoc., 13, 348.
Yatzidis, H. (1964). A convenient haemoperfusion micro-apparatus over charcoal for the treatment of endogenous and exogenous intoxications. Its use as an effective artificial kidney. Proc. Eur. Dial. Transpl. Assoc., 1, 83.
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© 1977 Bioengineering Unit, University of Strathclyde
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Sideman, S., Hoffer, E., Better, O.S., Lupovitch, S. (1977). Selective Removal of Phosphate Ions from the Blood of Uraemic Patients. In: Kenedi, R.M., Courtney, J.M., Gaylor, J.D.S., Gilchrist, T., Gerard, S.M. (eds) Artificial Organs. Strathclyde Bioengineering Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-03458-1_33
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DOI: https://doi.org/10.1007/978-1-349-03458-1_33
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