Summary
The widespread use of a haemoperfusion device (Haemocol™) containing coated granules in drug intoxication has led to its use in other clinical applications. The relative simplicity of the system, together with the ability of coated charcoal to adsorb a wide range of molecular species has encouraged clinical evaluation in acute hepatic failure and uraemia.
This use of adsorbents in extracorporeal circuits (ECC) is of particular significance because it represents the introduction of solid/liquid (i.e. blood) mass transfer systems to ECC and it offers the potential to remove specific toxins in varied clinical situations. This significant advance, however, has necessitated the development of test methods particularly relevant to this type of physical system and to the varied clinical uses.
Amongst the many in vitro and in vivo techniques used to characterise and evaluate adsorbent systems two will be described which are related particularly to performance and safety.
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(1)
In vitro simulation of haemoperfusion. The factors considered here include the adsorption/ desorption behaviour of the system and its effect upon rate of drug removal, total drug capacity of the system and duration of use.
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(2)
In vitro measurement of particle elution using simulated haemoperfusion.
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© 1977 Bioengineering Unit, University of Strathclyde
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Fennimore, J., Kolthammer, J.C., Lang, S.M. (1977). Evaluation of Haemoperfusion Systems: In Vitro Methods Related to Performance and Safety. In: Kenedi, R.M., Courtney, J.M., Gaylor, J.D.S., Gilchrist, T., Gerard, S.M. (eds) Artificial Organs. Strathclyde Bioengineering Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-03458-1_19
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