Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards

  • C. Lindberg
  • C. Bogentoft
  • B. Dahlström
  • L. Paalzow

Abstract

During recent years there has been an increasing interest in the relationship between the pharmacokinetics and the effects of various drugs. A better understanding of such relationships is a fundamental basis for establishing a correct therapeutic dosage regimen and the adjustment of this to individual variations in, for example, drug metabolism and response (Wagner, 1975; Jellett, 1976).

Keywords

Catheter Benzene Bromide Amide Morphine 

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References

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Copyright information

© The Contributors 1978

Authors and Affiliations

  • C. Lindberg
    • 1
  • C. Bogentoft
    • 1
  • B. Dahlström
    • 2
  • L. Paalzow
    • 2
  1. 1.Department of Organic Pharmaceutical ChemistryBiomedical CenterUppsalaSweden
  2. 2.Department of Pharmaceutical PharmacologyBiomedical CenterUppsalaSweden

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