Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards
During recent years there has been an increasing interest in the relationship between the pharmacokinetics and the effects of various drugs. A better understanding of such relationships is a fundamental basis for establishing a correct therapeutic dosage regimen and the adjustment of this to individual variations in, for example, drug metabolism and response (Wagner, 1975; Jellett, 1976).
KeywordsCatheter Benzene Bromide Amide Morphine
Unable to display preview. Download preview PDF.
- Klotz, U., McHorse, T. S., Wilkinson, G. R. and Schenker, S. (1974). Clin. Pharmacol. Ther. 16, 667Google Scholar
- Lindberg, C., Bogentoft, C. and Danielsson, B. (1974). Acta Pharm. Suec., 11, 201Google Scholar
- Mather, L. E., Tucker, G. T., Pflug, A. E., Lindop, M. J. and Wilkerson, C. (1975). Clin. Pharmacol. Ther. 17, 21Google Scholar
- Wagner, J. G. (1975). Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publ., Illinois, USAGoogle Scholar