Drug metabolism and pharmacokinetic studies in man utilising nitrogen-15- and deuterium-labelled drugs: the metabolic fate of cinoxacin and the metabolism and pharmacokinetics of propoxyphene
During the past several years, stable isotope utilisation has entered explosively into the clinical pharmacology laboratory for two major reasons: (1) the development of relatively simple, reliable instrumentation for gas chromatography—mass spectrometry (GC—MS) and (2) the availability of highly enriched stable-isotope-labelled starting materials. The techniques involved in mass spectrometry have been reviewed (Haet al., 1969; Gordon and Frigerio, 1972; Finnigan et al., 1974), as have the chemical aspects of stable isotope use (McCloskey, 1975). These reviews only scratch the surface of an enormous body of literature. Our application of these techniques to problems in clinical pharmacology forms the basis of this presentation as an encouragement to others.
KeywordsHPLC Starch Fractionation Hydrochloride Lactose
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