Structural and conformational studies on quinoxaline antibiotics in relation to the molecular basis of their interaction with DNA
Research into drug action at the molecular level must first and foremost be concerned with the physical interaction between a drug and its receptor, and then attempt to explain the sequence of events which connect that interaction with the physiological response. It is commonly envisaged that the binding of the drug to its receptor provokes conformational changes in the latter which act as the immediate trigger leading to the biological effect. Obviously a sine qua non for understanding these events is a fairly detailed knowledge of the nature of the receptor and its conformation in the unperturbed state. Needless to say, the receptor is generally reckoned to be a macromolecule of some sort — quite likely (but not necessarily) a protein.
KeywordsMacromolecule Sine Ethidium Pyrimidine Purine
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