Abstract
It is not necessary to define too closely the term ‘peptide hormone’. It is used, in this contribution, to mean a polypeptide of known constitution, with a molecular weight of less than 10 000 daltons which has, or may be presumed to have, hormonal activity. Within this broad definition, with one exception (parathyroid hormone), all peptide hormones produced in or outside the central nervous system are derived from a series of cells which possess a number of common cytochemical and ultrastructural characteristics. For this reason they have been grouped together as the APUD series of endocrine polypeptide cells (Pearse, 1968, 1969), deriving their name as an acronym from their most important and constant cytochemical properties (Amine content and/or Amine Precursor Uptake and Decarboxylation). The remaining cytochemical characteristics (masked metachromasia, high a-glycerophosphate dehydrogenase, high non-specific esterase and/or cholinesterase) and the ultrastructural characteristics, of which the most notable is the presence of storage granules (100–350nm in diameter), need not concern us at this point.
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© 1976 Institute of Biology Endowment Trust Fund
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Pearse, A.G.E. (1976). Evolutionary and developmental relationships among the cells producing peptide hormones. In: Parsons, J.A. (eds) Peptide Hormones. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-02718-7_3
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