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Human chorionic gonadotropin

  • Chapter
Book cover Peptide Hormones

Part of the book series: Biological Council ((BCSDA))

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Abstract

Human chorionic gonadotropin (hCG) is a glycoprotein hormone that is synthesised by the syncytiotrophoblast cells of the placenta. The hormone is homologous in structure with human luteinising hormone (hLH) and shares with hLH similar qualitative biological actions on the ovary and the testis (Bishop, Nureddin and Ryan, 1976). Whereas the major function of hLH in women is to act synergistically with FSH to produce ovulation and initiate development of the corpus luteum, the function that hCG appears to serve is to convey a hormonal stimulus from the implanted, fertilised ovum to the corpus luteum which calls forth an augmented production of steroid hormones. Its action in the first few days after fertilisation stimulates secretion of oestrogen and progestins by the corpus luteum to prevent the decline in luteal function that normally occurs in an infertile menstrual cycle (Ross et al., 1970; Vande Wiele et al., 1970). hCG is bound at the same receptors as hLH in the ovary (Kammerman et al., 1972; Gospodarowicz, 1973) and the testis (Catt and Dufau, 1973).

Supported by NIH Research Grant AM-09579 and NICHHD Contract 70-2251.

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Author notes

  1. F. J. Morgan

    Present address: Victoria Parade, St. Vincent’s School of Medical Research, Melbourne, Victoria 3065, Australia

Authors and Affiliations

  1. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA

    R. E. Canfield, S. Birken, J. H. Morse & F. J. Morgan

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  1. R. E. Canfield
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  2. S. Birken
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  3. J. H. Morse
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  4. F. J. Morgan
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Editor information

Editors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, UK

    J. A. Parsons M.A., B.M., B.Ch.

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© 1976 Institute of Biology Endowment Trust Fund

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Canfield, R.E., Birken, S., Morse, J.H., Morgan, F.J. (1976). Human chorionic gonadotropin. In: Parsons, J.A. (eds) Peptide Hormones. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-02718-7_15

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