Increased albumin catabolism in early uremia as a cause of protein depletion

  • R. Bianchi
  • G. Mariani
  • A. Pilo
  • F. Carmassi
  • M. G. Toni

Abstract

The present study was undertaken with the aim of assessing acute changes of albumin turnover in the early phase of uremia, in order to explain the pathogenesis of protein depletion in that condition1 – 3. Previous turnover tracer experiments have shown that such a depleted state does not depend on protein restriction in the diet followed by the patients, assuming that the uremics were in a metabolic steady-state at the time of the study1 – 3. Therefore, it was supposed that some rapid transitory changes of albumin turnover occurred in the early phase of renal failure, during which catabolism exceeds production, without compensation by subsequent periods of relative excess production.

Keywords

Filtration Albumin Urea Europe Creatinine 

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References

  1. 1.
    Bianchi, R., Mariani, G., Pilo, A. and Donato, L. (1971). Albumin metabolism in patients with chronic renal failure on low protein balanced diet. In Protides of the Biological Fluids, 19th ed., H. Peeters, ed., Pergamon Press, Oxford, p. 483Google Scholar
  2. 2.
    Bianchi, R., Mariani, G. and Pilo, A. (1972). Albumin metabolism in uremic patients on low-protein diet. In Uremia, R. Kluthe, G. M. Berlyne and B. T. Burton, eds., Georg Thieme Verlag, Stuttgart, p. 206Google Scholar
  3. 3.
    Bianchi, R., Mariani, G., Pilo, A., Toni, M. G. and Carmassi, F. Albumin depletion in uremic patients on conservative management. In this volume, p. 237Google Scholar
  4. 4.
    Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. (1974) Albumin catabolic rate during peritoneal dialysis in acute and chronic uremia. In Protides of the Biological Fluids, 21st ed., H. Peeters, ed., Pergamon Press, p. 441CrossRefGoogle Scholar
  5. 5.
    Mariani, G., Bianchi, R., Pilo, A., Palla, R., Toni, M. G. and Fusani, L. Albumin catabolism measurement by a double tracer technique in uremic patients during a single dialytic treatment. Europe. J. Clin. Invest., 4 (1974), 435Google Scholar
  6. 6.
    Monasterio, G. (1970) Le Nefropatie Mediche. USES, FirenzeGoogle Scholar
  7. 7.
    Rosa, U., Pennisi, F., Bianchi, R., Federighi, G. and Donato, L. Chemical and biological effects of iodination on human albumin. Biochim. Biophys. Acta, 133 (1967), 486CrossRefGoogle Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • R. Bianchi
  • G. Mariani
  • A. Pilo
  • F. Carmassi
  • M. G. Toni

There are no affiliations available

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