The effects of drugs on the concentrations of some organic acids in human cerebrospinal fluid

Roos, B.-E.

doi:10.1007/978-1-349-02273-1_19

B.-E. Roos²

Part of the book series: Biological Council

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Abstract

The metabolic pathways of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the central nervous system are well known. DA is inactivated either interneuronally by monoamine oxidase (MAO) to dihydroxyphenylacetic acid, which in turn is converted to homovanillic acid (HVA) by catechol-O-methyltransferase (COMT) or by COMT to methoxytyramine and then by MAO to HVA. 5-Hydroxytryptamine is inactivated by MAO to 5-hydroxyindolyl-3-acetic acid (5-HIAA).

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Department of Pharmacology, University of Göteborg, Fack, S-400 33, Göteborg 33, Sweden
B.-E. Roos

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B.-E. Roos
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Department of Pharmacology, University of Cambridge, UK
B. A. Callingham

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Roos, BE. (1973). The effects of drugs on the concentrations of some organic acids in human cerebrospinal fluid. In: Callingham, B.A. (eds) Drugs and Transport Processes. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-02273-1_19

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DOI: https://doi.org/10.1007/978-1-349-02273-1_19
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-02275-5
Online ISBN: 978-1-349-02273-1
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