This review has emphasised the importance of precise stereochemical data in the determination of the structural basis of metal-ion function and reactivity in proteins and enzymes. The resolving power of protein X-ray crystallography has been discussed in general to indicate the origins of the approximate stereochemical data characteristic of protein structures at present, in comparison to the results of small-molecule X-ray crystallography. Possible directions through which improved stereochemical detail of proteins may be obtained in the future have been briefly discussed, especially with respect to their metal-ligand co-ordination centres.


Hydrolysis Carbonyl Porphyrin 

Copyright information

© Palgrave Macmillan, a division of Macmillan Publishers Limited 1975

Authors and Affiliations

  • C. A. Mcauliffe
    • 1
  1. 1.Institute of Science and TechnologyUniversity of ManchesterUK

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