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Effects of Drugs on Cellular Control Mechanisms pp 131–150Cite as

Steroids and the Development of Mammary Epithelial Cells

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Part of the book series: Biological Council ((BCSDA))

Abstract

Mammary gland tissue from immature mice [1] , adult virgin mice [2] and pregnant mice [3] can be stimulated to differentiate in vitro. Additions of insulin, glucocorticoid and prolactin to the synthetic culture medium are required for the complex sequence of cellular events which culminates in the synthesis of secretory proteins such as casein [3]. The interplay of these hormones during development of mouse mammary epithelial cells, in vitro, is the subject of this discussion, with particular emphasis on the roles of the steroids.

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Abbreviations

AIB:

α-Amino-isobuytil acid.

RER:

Rough endoplasmic reticulum.

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Author information

Authors and Affiliations

  1. National Institute of Arthritis and Metabolic Diseases, National Institute of Health, Bethesda, Maryland, 20014, USA

    Yale J. Topper & Takami Oka

Authors
  1. Yale J. Topper
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  2. Takami Oka
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, University College, London, UK

    B. R. Rabin

  2. Biology Laboratory, University of Kent, Canterbury, UK

    R. B. Freedman

Copyright information

© 1971 Institute of Biology Endowment Fund

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Topper, Y.J., Oka, T. (1971). Steroids and the Development of Mammary Epithelial Cells. In: Rabin, B.R., Freedman, R.B. (eds) Effects of Drugs on Cellular Control Mechanisms. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-01321-0_7

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